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The Beautiful Cure
“A terrific book by a consummate storyteller and scientific expert considers the past and future of the body’s ability to fight disease and heal itself.” —Adam Rutherford, The Guardian The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body’s ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major adva...
Generation and Effector Functions of Regulatory Lymphocytes
Over the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions are diverse and can sometimes easily be lost, and it is not well understood how they interact with anti...
The Molecular Mechanisms of Regulatory T cell Immunosuppression
Ever since Regulatory T cells (T-Regs) were first defined as peripheral CD4+ T cells that express the interleukin-2 (IL-2) receptor alpha chain (IL-2Ra), there have been intensive efforts to determine the molecular mechanisms whereby this minor subset of CD4+ T cells (~ 5-10%) nonspecifically suppresses all potential effector T cells, whether reactive to self or non-self antigens. Multiple possible molecular mechanisms have been implicated, including the scavenging of IL-2 via the expression of high densities of IL-2Rs, the inhibition of antigen presentation via CTLA-4 molecules leading to decreased IL-2 production, the activation of intracellular cAMP thereby suppressing both IL-2 productio...
Co-signal Molecules in T Cell Activation
This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
Encyclopedia of Molecular Mechanisms of Disease
This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.
Regulatory T Cells in Inflammation
Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.
Clinical Immunology,Principles and Practice (Expert Consult - Online and Print),4
Written and edited by international leaders in the field, this book has, through two best-selling editions, been the place to turn for authoritative answers to your toughest challenges in clinical immunology. Now in full color and one single volume, the 3rd Edition brings you the very latest immunology knowledge - so you can offer your patients the best possible care. The user-friendly book and the fully searchable companion web site give you two ways to find the answers you need quickly...and regular online updates keep you absolutely current. Leading international experts equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of im...
The Quantal Theory of Immunity
This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to ?count? the number of foreign antigenic molecular ?hits?, and they only react when a critica...
The Hereditary Basis of Rheumatic Diseases
Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular tools. The volume is essential reading for researchers and clinicians from rheumatology, inflammation research, immunology, and cell and molecular biology.
Janeway's Immunobiology
Janeway's Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introductory text, all students will appreciate the book's clear writing and informative illustrations, and advanced students and working immunologists will appreciate its comprehensive scope and depth. Janeway's I
