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Glycans: Molecules at the Interface of Immunity and Disease
Glycans are complex, multi-unit carbohydrate structures that cover the surfaces of cells and guide cellular interactions. Glycobiology studies the synthesis, structure, function, regulation, and evolution of glycans and glycan-binding molecules. Glycans are synthesized and added as modifications to proteins, lipids, and RNA. Though they are often associated with functions outside of cells (glycoproteins and glycolipids are most often extracellular or secreted), glycans are also active within cells. Glycans are known to have diverse physiological roles ranging from cell adhesion (maintaining tissue structure and integrity) to molecular recognition (marking position during development, or self-identity in immunity and reproduction). Glycans also regulate cellular activity and physiological state. The families of proteins that bind glycans are called lectins. Glycans and lectins are vital in many diseases such as cancer, neurodegeneration, inflammation, allergies, asthma, and autoimmune disorders.
Novel biomarkers in tumor immunity and immunotherapy
Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies are highly effective against many types of cancer, yet durable responses are limited to a subset of patients highlighting the need for the development of effective biomarkers to predict prognosis and efficacy. Currently, PD-L1 expression in tumors, microsatellite instability (MSI) or mismatch repair deficiency (dMMR), and tumor mutation burden (TMB) are known as biomarkers for cancer immunotherapy but are not sufficient. Combination therapy with immune checkpoint inhibitors and chemotherapy or radiation therapy, as well as diverse therapies targeting intra-tumoral regulatory T cells have been described, but there...
Antimicrobial Resistance
Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.
The Terrorist Prince
Murtaza Bhutto, 1954-1996, political leader from Pakistan.
Calcium Entry Channels in Non-Excitable Cells
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
From Kamptee to Dallas
Web Text Introduction There is a general perception about the authors of autobiographies that they tell truth about other people while they need to tell truth about themselves. I have tried to be objective throughout my book and highlighted my failures and mistakes too. The present book is an account of my life that began on February 8, 1947, when I was born in the Sarpanch Mohammad Khurshid Haq family in a small town on the banks of the river Kanhan known as Kamptee in India. Sarpanch is a title used for the head of Panchayat. The title remained in our family for three generations. After my father died, Anis bhaijan (elder brother) would have become the next sarpanch, but he had already mig...
Human Evolution
Brings together new research demonstrating how evidence based on genetic phenomena should end any lingering controversy over human evolution.
Allelopathy
Allelopathic studies may be defined in various aspects; weed against weed/crop and vice versa. This book focuses on the ways to utilize the allelopathic potential of weeds or crops for controlling weeds in the agroecosystems. Vigorous use of herbicides is poisoning our environment at an alarming rate; allelopathy can be employed as a useful alternative to control weeds naturally under field conditions. The book contains chapters on the history of allelopathy; allelopathic potential of several important crops (rice, wheat, sorghum, maize, mustard, sunflower) and weeds (members of Solanaceae, Convolvulaceae, Asteraceae, Verbenaceae). Moreover, it highlights how the allelopathic potential of these weeds and crops can be employed effectively to suppress weeds under field conditions. The book also discusses topics on the role of allelochemicals in agroecosystems; impact on local flora; biotic stress induced by allelochemicals; mechanism of action of allelochemicals and future prospective of allelopathy. Prepared with basic concepts and importance of allelopathy, this book is intended for the agricultural community, botanists, students and researchers.
Advances in Environmental Pollution Management: Wastewater Impacts and Treatment Technologies
Advances in Environmental Pollution Management: Wastewater Impacts and Treatment Technologies has been designed to bind novel knowledge of wastewater pollution-induced impacts on various aspects of our environment. The book also contains novel methods and tools for the monitoring and treatment of produced wastewater.
