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The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has profoundly shifted the paradigms of molecular cancer research and drug discovery. The intricate networks of immune-inflammatory cells and signalling, cancer-associated fibroblasts, endothelial cells and adipose cells are extensively researched for diagnostics, therapeutics and predictive values. This includes siRNA and miRNA nanotherapeutics targeting these molecular components, owing to their powerful gene-silencing properties. Despite the concerted effort in the development of drug targeting TME, such as BLZ945 (a colony-stimulating factor-1 receptor inhibitor), there is a void in clinically satisfactory drug to target this intricate factor, thus far.
This book puts forward a new perspective, the historical dynamics of Chinese politics, for better understanding China’s politics, which is from the vertical history of China and the dimension of horizontal world politics, combining the historical analysis of how Chinese politics has come along the way and the comparative analysis of China's governance achievements in world politics. Based on this premise, this book attempts to explain the democratic discourse of contemporary Chinese political logic. The historical dynamics of Chinese politics comes from long-term communication between the author and Western scholars, which may help the global audience to understand China’s politics from all angles.
This book is intended for medical students unfamiliar with electrocardiograms (ECG); anyone just getting started with ECG can use this book to start from scratch. After familiarizing themselves with this simple and practical method for interpreting ECG, readers will discover how to quickly and easily read ECG strips without overlooking potentially abnormal conditions. Based on the authors’ substantial experience, which is compared with other ECG interpretation methods and combined with traditional guidelines, the book equips readers with the fundamental knowledge and skills needed to rapidly and accurately read and interpret ECG.
This book explores China’s digital discourse and how the Internet influences social and ideological changes to the country’s political economy, within China’s historical context and through a variety of social and political actors. Analysing discourses as diverse as policy papers, addresses from the Xi-Li Administration, and speeches from CEOs of the dominant Internet companies in China, as well as those of Chinese Internet Users, this book illuminates the dynamics, complexity, and structural contradictions in China’s current network technology-enabled developmental path through the lens of ideology and discourse. The book proposes a multi-dimensional model to understand Marxist ideologies under capitalism, emphasizing the relevance of alienation, commodity fetishism, and reification in contemporary discussions of ideology and discourse. This insightful study offers fresh insights into Chinese digital discourse and will be of interest to upper-level students and scholars of communication studies, digital media, sociology, political science, and Internet and technology studies.
This book comprises select peer-reviewed proceedings of the 6th International Conference on Innovative Computing (IC 2023). The contents focus on communication networks, business intelligence and knowledge management, web intelligence, and fields related to the development of information technology. The chapters include contributions on various topics such as databases and data mining, networking and communications, web and Internet of Things, embedded systems, soft computing, social network analysis, security and privacy, optical communication, and ubiquitous/pervasive computing. This volume will serve as a comprehensive overview of the latest advances in information technology for those working as researchers in both academia and industry.
This book introduces the Five-hundred-meter Aperture Spherical Radio Telescope (FAST), also known as the "The Sky Eye", one of the China’s big science facilities. Using easy-to-understand language, the book covers the scientific background, construction process, achievements, and effects of FAST on the development of the national economy. With a large number of intuitive and vivid images and videos, the book presents basic information on FAST for general readers who are interested in astronomy.
This book constitutes the refereed proceedings of the 2021 International Conference on Business Intelligence and Information Technology (BIIT 2021) held in Harbin, China, during December 18–20, 2021. BIIT 2021 is organized by the School of Computer and Information Engineering, Harbin University of Commerce, and supported by Scientific Research Group in Egypt (SRGE), Egypt. The papers cover current research in electronic commerce technology and application, business intelligence and decision making, digital economy, accounting informatization, intelligent information processing, image processing and multimedia technology, signal detection and processing, communication engineering and technology, information security, automatic control technique, data mining, software development, and design, blockchain technology, big data technology, artificial intelligence technology.