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Direito penal negocial
O sistema de justiça criminal adotado no Brasil, arraigado por uma postura eminentemente conflitiva e processual, não tem atendido aos reclamos sociais de celeridade e eficiência, revelando-se como imperiosa a adoção de mecanismos outros, especialmente de caráter consensual, na resolução de conflitos de natureza penal. Nesta obra, busca-se compreender o arcabouço do modelo processualista penal vigente no Brasil, para em seguida, em contraponto, demonstrar como alguns outros países abriram suas portas à incidência da perspectiva negocial penal. Em um segundo momento, passa-se à análise do cenário fático-jurídico de outros Ministérios Públicos brasileiros, bem como do Ministério Público do Estado de Roraima, com ênfase nos mecanismos de fomento à conduta dialogal na seara resolutiva penal e em especial do acordo de não persecução penal. Ao final, demonstram-se as vantagens para os atores do palco jurídico e da vida cotidiana, com a adoção de um sistema de resposta pactuada em âmbito penal, notadamente por meio da instalação de uma Central especializada para tal fim, no âmbito do Ministério Público roraimense.
Melodious Accord
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Combinatorial Chemistry and Molecular Diversity in Drug Discovery
Increasing pressure to identify, optimize, develop, and commercialize novel drugs more rapidly and more cost-effectively has led to an urgent demand for technologies that can reduce the time to market for new products. Molecular diversity, of both natural and synthetic materials, provides a valuable source of compounds for identifying and optimizing new drug leads. Through the rapidly evolving technology of combinatorial chemistry, it is now possible to produce libraries of small molecules to screen for novel bioactivities. This powerful new technology has begun to help pharmaceutical companies find new drug candidates quickly, save significant dollars in preclinical development costs, and ultimately change their fundamental approach to drug discovery. Included among the many topics: Historical background. Library strategy and design. Solid-phase synthesis. Small molecular libraries. Automation, analytical, and computational methodology. Biological diversity. Strategies for screening combinatorial libraries. Combinatorial drug screening and development. Combinatorial chemistry information management.
Drawing Futures
Drawing Futures brings together international designers and artists for speculations in contemporary drawing for art and architecture.Despite numerous developments in technological manufacture and computational design that provide new grounds for designers, the act of drawing still plays a central role as a vehicle for speculation. There is a rich and long history of drawing tied to innovations in technology as well as to revolutions in our philosophical understanding of the world. In reflection of a society now underpinned by computational networks and interfaces allowing hitherto unprecedented views of the world, the changing status of the drawing and its representation as a political act ...
Successful Drug Discovery, Volume 1
The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
Against Architecture
Over the past 30 years the writings of Georges Bataille have had a profound influence on French intellectual thought, informing the work of Foucault, Derrida, and Barthes, among others. Against Architecture offers the first serious interpretation of this challenging thinker, spelling out the profoundly original and radical nature of Bataille's work.
The Gothic Cathedral
The description for this book, The Gothic Cathedral: Origins of Gothic Architecture and the Medieval Concept of Order, will be forthcoming.
Handbook of Clinical Drug Data
This handbook, which in its early lustrous years served physicians, pharmacists, and pharmacy students, is unlike any other drug reference book in that it allows readers to compare and contrast various drugs within drug categories, thereby enabling them to make decisions on which drug to administer. All other drug reference books merely repeat the drug manufacturers' literature, with no analysis of that information. Nor are there any reports from the published literature concerning use and efficacy of the drugs listed. The clinical drug information with part II contains chapters on drug-induced diseases, drug interactions and interferences, drug use in special populations, immunization, medi...
