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Computational biology is a rapidly expanding field, and the number and variety of computational methods used for DNA and protein sequence analysis is growing every day. These algorithms are extremely valuable to biotechnology companies and to researchers and teachers in universities. This book explains the latest computer technology for analyzing DNA, RNA, and protein sequences. Clear and easy to follow, designed specifically for the non-computer scientist, it will help biologists make better choices on which algorithm to use. New techniques and demonstrations are elucidated, as are state-of-the-art problems, and more advanced material on the latest algorithms. The primary audience for this ...
Molecular networks provide descriptions of the organization of various biological processes, including cellular signaling, metabolism, and genetic regulation. Knowledge on molecular networks is commonly used for systems level analysis of biological function; research and method development in this area has grown tremendously in the past few years. This book will provide a detailed review of existing knowledge on the functional characterization of biological networks. In 15 chapters authored by an international group of prolific systems biology and bioinformatics researchers, it will organize, conceptualize, and summarize the existing core of research results and computational methods on understanding biological function from a network perspective.
Constraints and Databases contains seven contributions on the rapidly evolving research area of constraints and databases. This collection of original research articles has been compiled as a tribute to Paris C. Kanellakis, one of the pioneers in the field. Constraints have long been used for maintaining the integrity of databases. More recently, constraint databases have emerged where databases store and manipulate data in the form of constraints. The generality of constraint databases makes them highly attractive for many applications. Constraints provide a uniform mechanism for describing heterogenous data, and advanced constraint solving methods can be used for efficient manipulation of constraint data. The articles included in this book cover the range of topics involving constraints and databases; join algorithms, evaluation methods, applications (e.g. data mining) and implementations of constraint databases, as well as more traditional topics such as integrity constraint maintenance. Constraints and Databases is an edited volume of original research comprising invited contributions by leading researchers.
Current PPI databases do not offer sophisticated querying interfaces and especially do not integrate existing information about proteins. Current algorithms for PIN analysis use only topological information, while emerging approaches attempt to exploit the biological knowledge related to proteins and kinds of interaction, e.g. protein function, localization, structure, described in Gene Ontology or PDB. The book discusses technologies, standards and databases for, respectively, generating, representing and storing PPI data. It also describes main algorithms and tools for the analysis, comparison and knowledge extraction from PINs. Moreover, some case studies and applications of PINs are also discussed.
Knowledge discovery and data mining have become areas of growing significance because of the recent increasing demand for KDD techniques, including those used in machine learning, databases, statistics, knowledge acquisition, data visualization, and high performance computing. In view of this, and following the success of the five previous PAKDD conferences, the sixth Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD 2002) aimed to provide a forum for the sharing of original research results, innovative ideas, state-of-the-art developments, and implementation experiences in knowledge discovery and data mining among researchers in academic and industrial organizations. Muc...
This edited collection describes recent progress on lazy learning, a branch of machine learning concerning algorithms that defer the processing of their inputs, reply to information requests by combining stored data, and typically discard constructed replies. It is the first edited volume in AI on this topic, whose many synonyms include `instance-based', `memory-based'. `exemplar-based', and `local learning', and whose topic intersects case-based reasoning and edited k-nearest neighbor classifiers. It is intended for AI researchers and students interested in pursuing recent progress in this branch of machine learning, but, due to the breadth of its contributions, it should also interest researchers and practitioners of data mining, case-based reasoning, statistics, and pattern recognition.
The third in an informal series of books about parallel processing for Artificial Intelligence, this volume is based on the assumption that the computational demands of many AI tasks can be better served by parallel architectures than by the currently popular workstations. However, no assumption is made about the kind of parallelism to be used. Transputers, Connection Machines, farms of workstations, Cellular Neural Networks, Crays, and other hardware paradigms of parallelism are used by the authors of this collection.The papers arise from the areas of parallel knowledge representation, neural modeling, parallel non-monotonic reasoning, search and partitioning, constraint satisfaction, theorem proving, parallel decision trees, parallel programming languages and low-level computer vision. The final paper is an experience report about applications of massive parallelism which can be said to capture the spirit of a whole period of computing history.This volume provides the reader with a snapshot of the state of the art in Parallel Processing for Artificial Intelligence.
Numerical Control: Part B, Volume 24 in the Handbook of Numerical Analysis series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this volume include Control problems in the coefficients and the domain for linear elliptic equations, Computational approaches for extremal geometric eigenvalue problems, Non-overlapping domain decomposition in space and time for PDE-constrained optimal control problems on networks, Feedback Control of Time-dependent Nonlinear PDEs with Applications in Fluid Dynamics, Stabilization of the Navier-Stokes equations - Theoretical and numerical aspects, Reconstruction...
Advances in computer science and technology and in biology over the last several years have opened up the possibility for computing to help answer fundamental questions in biology and for biology to help with new approaches to computing. Making the most of the research opportunities at the interface of computing and biology requires the active participation of people from both fields. While past attempts have been made in this direction, circumstances today appear to be much more favorable for progress. To help take advantage of these opportunities, this study was requested of the NRC by the National Science Foundation, the Department of Defense, the National Institutes of Health, and the Department of Energy. The report provides the basis for establishing cross-disciplinary collaboration between biology and computing including an analysis of potential impediments and strategies for overcoming them. The report also presents a wealth of examples that should encourage students in the biological sciences to look for ways to enable them to be more effective users of computing in their studies.
This book constitutes the refereed proceedings of the 10th International Conference on Artificial Intelligence: Methodology, Systems, and Appliations, AIMSA 2002, held in Varna, Bulgaria in September 2002. The 26 revised full papers presented together with 2 invited papers were carefully reviewed and selected for inclusion in this book. The papers address a broad spectrum of topics in AI, including natural language processing, computational learning, Machine learning, AI planning, heuristics, neural information processing, adaptive systems, computational linguistics, multi-agent systems, AI logic, knowledge management, and information retrieval.