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Fast Facts: Comprehensive Genomic Profiling
Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy
Immunotherapy and Small Molecule Inhibitors as Combinational Cancer Therapeutics
Cancer is a multifactorial chronic disease, in which several factors contribute to its pathogenesis and progression. Our immune system is designed to continuously identify and destroy tumor or aberrant cells. However, a compromised immune system has been associated with the development of cancer. In such immune state, cancer cells often develop the ability to hide from the immune surveillance network and adopt intelligent survival tactics which are continuously developing. Therefore, researchers are focusing on boosting anti-tumor immunity by developing novel cancer immunotherapies. Adoptive cell-based cancer therapies are being used, including in vitro expansion and activation of immune eff...
Parliamentary Papers
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'Heimat'
The concept of Heimat with its seemingly pre- or anti-modern connotations of rootedness in a place of origin is central to a critical understanding of German history and culture. Over the course of the past fifteen years, scholars across a range of disciplines have found new ways to examine the changing notions of Heimat – its multifaceted cultural, literary, and visual history, its gendered connotations, and its national and ideological appropriations. This anthology is the first to examine cultural manifestations of Heimat by giving special consideration to issues of memory and space. The contributions to this volume challenge static notions of place often associated with Heimat. Instead...
The Rule of Christ: Themes in the Theology of James Nayler
This study explores theological themes visible within the writings of James Nayler, and locates them within their radical religious context. There is a powerful Christological vision at the heart of Nayler’s religious thought that engendered a practical theology with radical political, economic, and ecological implications.
Pathology and Genetics of Tumours of Soft Tissue and Bone
This vol. was produced in collaboration with the International Academy of Pathology (IAP).
Annual report
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Lists and Indexes
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