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Life-threatening organ dysfunction/failure in critically ill patients suffering from sepsis or trauma is caused by a dysregulated host response to infection and/or inflammation. Despite significant advances in our understanding of some of the key signaling pathways involved in the excessive inflammation associated with sepsis/trauma, the translation of our current understanding of the underlying pathophysiology into organ-protective therapeutic strategies is still very limited. Current therapeutic approaches, hence, continue to rely on source control, antibiotics and supportive care, and particularly early goal-directed therapy.
Anästhesiologie - Kritische Risikoabschätzung, sorgfältige Planung, optimale Versorgung! Grundlagen - Geschichte - Rechtliche Aspekte - Pharmakologie - Arbeitstechniken Physiologie, Pathophysiologie und Anästhesie bei Begleiterkrankungen - Nervensystem, Lunge, Herz-Kreislauf, Sauerstoff-Transport, Säure- Basen-Haushalt, Hämatologie, Gerinnung, Niere, Leber, Magen-Darm-Trakt, Stoffwechsel, endokrines System, Immunsystem, Haut, Bindegewebe, muskuloskelettales System Allgemeine Anästhesiologie - Diagnostische Verfahren, Anästhesievorbereitung - Intraoperative Überwachung - Allgemeinanästhesie - Regionalanästhesie - Postoperative Phase Spezielle Anästhesiologie - Viszeralchirurgie, G...
This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
Over 1 million sold in series! The key to adventure lies within your imagination! Cousins Patrick and Beth go to the Holy Land in the tenth century BC. Their goal is to get back the ring Hugh stole and return him to 1450s England where he belongs. But troubles await them as soon as they step out of the Imagination Station. First they meet an angry bear and later an angry giant. Set against the backdrop of the David and Goliath story, the cousins learn that having a giant faith is more important than having a giant on your side.
Endoscopic Ear Surgery: Principles, Indications, and Techniques Increasingly used as an adjunctive tool in the diagnosis and management of ear disease, middle ear endoscopy has the potential to decrease patient morbidity, prevent disease recurrence, and reduce costs. Its capacity to uncover "hidden" anatomy within the small dimensions of the ear has made it essential for functional surgery, allowing surgeons to preserve key anatomic structures such as the cochlea and facial nerve. Now for the first time, the physicians who pioneered this groundbreaking minimally invasive technique review its indications, advantages, disadvantages, and surgical approaches: Written by the foremost leaders in t...
Whilst financial rights have appeared as a successful ingredient in North-American power markets, they have their shortcomings both theoretically and in practice. Financial Transmission Rights: Analysis, Experiences and Prospects present a systematic and comprehensive overview of financial transmission rights (FTRS). Following a general introduction to FTRs, including chapters to explain transmission pricing and the general properties of FTRS, experts in the field provide discussions on wide scope of topics. These include: Varying perspectives on FTRS: from electrical engineers to economists, Different mathematical formulations of FTRS Financial Hedging using FTRS, and Alternative solutions ...