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Life-threatening organ dysfunction/failure in critically ill patients suffering from sepsis or trauma is caused by a dysregulated host response to infection and/or inflammation. Despite significant advances in our understanding of some of the key signaling pathways involved in the excessive inflammation associated with sepsis/trauma, the translation of our current understanding of the underlying pathophysiology into organ-protective therapeutic strategies is still very limited. Current therapeutic approaches, hence, continue to rely on source control, antibiotics and supportive care, and particularly early goal-directed therapy.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
This book provides a unique overview of different approaches to developing software that is flexible, adaptable and easy to maintain and reuse. It covers the most recent advances in software architecture research. In addition, it provides the reader with scalable solutions for engineering and reengineering business processes, including architectural components for business applications, framework design for Internet distributed business applications, and architectural standards for enterprise systems.
This volume contains a selection of chapters based on papers to be presented at the Fifth Statistical Challenges in Modern Astronomy Symposium. The symposium will be held June 13-15th at Penn State University. Modern astronomical research faces a vast range of statistical issues which have spawned a revival in methodological activity among astronomers. The Statistical Challenges in Modern Astronomy V conference will bring astronomers and statisticians together to discuss methodological issues of common interest. Time series analysis, image analysis, Bayesian methods, Poisson processes, nonlinear regression, maximum likelihood, multivariate classification, and wavelet and multiscale analyses are all important themes to be covered in detail. Many problems will be introduced at the conference in the context of large-scale astronomical projects including LIGO, AXAF, XTE, Hipparcos, and digitized sky surveys.
Based on more than thirty years of research gleaned from Tibetan, Indian, and other cultures, The Healing Power of the Mind provides both spiritual insight and practical advice concerning the true nature of healing, showing how imagination, desire, the power of suggestion, psychic influence and the removal of limitations are valuable tools for maximizing our innate capacity for self-healing. In the spirit of Bernie Siegel's Love, Medicine and Miracles, Dr. Alexander's book explores the body/mind connection and its enormous relevance to health. Originally published as a handbook for Dr. Alexander's patients and later as a popular paperback published by Warner Destiny books, this is a classic which has helped thousands find their way to health.
This book provides a unique overview of different approaches to developing software that is flexible, adaptable and easy to maintain and reuse. It covers the most recent advances in software architecture research. In addition, it provides the reader with scalable solutions for engineering and reengineering business processes, including architectural components for business applications, framework design for Internet distributed business applications, and architectural standards for enterprise systems.