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Genes and Autoimmunity
  • Language: en
  • Pages: 280

Genes and Autoimmunity

Autoimmune disorders are known to affect a substantial number of people worldwide, demonstrating a gender bias and are the second largest cause of chronic illness. Recently, the attention has been focused on lifestyle changes as a major factor in the rise of autoimmune disease frequency. The two sections of this book are focused on the new opportunities for moving research forward, leading to a new approach to prevention and treatment of autoimmune diseases. A better understanding of the mechanisms of gene expression and triggering signaling pathways, which is involved in autoimmune pathogenesis simultaneously with current data for the interaction of microbiota with human immune system, will help to better understand the immune imbalance implicated in autoimmunity.

New Insights into Inflammatory Bowel Disease
  • Language: en
  • Pages: 266

New Insights into Inflammatory Bowel Disease

The incidence of chronic inflammatory and autoimmune diseases is steadily increasing. Inflammatory bowel disease (IBD) is one example of a chronic inflammatory disease, which primarily affects the intestine but may also affect extraintestinal organs. The exact pathogenesis of IBD is currently unknown. However, it is clear that the pathogenesis is complex, involving barrier defects, changes in the intestinal microbiome, and chronic immune activation. This book aims to summarize basic aspects of these complex interactions between barrier function, microbiome, and the immune system. Of note, there is currently no cure for IBD. However, several therapies have evolved in the last years, which are overall able to-at least temporarily-suppress IBD. These therapies and the underlying mechanism are discussed.

Colorectal Cancer Biology
  • Language: en
  • Pages: 462

Colorectal Cancer Biology

Colorectal cancer is a common disease, affecting millions worldwide and represents a global health problem. Effective therapeutic solutions and control measures for the disease will come from the collective research efforts of clinicians and scientists worldwide. This book presents the current status of the strides being made to understand the fundamental scientific basis of colorectal cancer. It provides contributions from scientists, clinicians and investigators from 20 different countries. The four sections of this volume examine the evidence and data in relation to genes and various polymorphisms, tumor microenvironment and infections associated with colorectal cancer. An increasingly better appreciation of the complex inter-connected basic biology of colorectal cancer will translate into effective measures for management and treatment of the disease. Research scientists and investigators as well as clinicians searching for a good understanding of the disease will find this book useful.

Bulgarian National bibliography
  • Language: bg
  • Pages: 880

Bulgarian National bibliography

  • Type: Book
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  • Published: 1993-04
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  • Publisher: Unknown

None

Colorectal Cancer Biology
  • Language: en

Colorectal Cancer Biology

  • Type: Book
  • -
  • Published: 2012-02-10
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  • Publisher: IntechOpen

Colorectal cancer is a common disease, affecting millions worldwide and represents a global health problem. Effective therapeutic solutions and control measures for the disease will come from the collective research efforts of clinicians and scientists worldwide. This book presents the current status of the strides being made to understand the fundamental scientific basis of colorectal cancer. It provides contributions from scientists, clinicians and investigators from 20 different countries. The four sections of this volume examine the evidence and data in relation to genes and various polymorphisms, tumor microenvironment and infections associated with colorectal cancer. An increasingly better appreciation of the complex inter-connected basic biology of colorectal cancer will translate into effective measures for management and treatment of the disease. Research scientists and investigators as well as clinicians searching for a good understanding of the disease will find this book useful.

Paediatric Nephrology
  • Language: en
  • Pages: 657

Paediatric Nephrology

This pocket-sized book is designed to provide up-to-date information for the general paediatrican and paediatric nephrologist, including advice on care of emergencies, chronic disorders and covering common and rare conditions. It is highly relevant for the day-to-day care of patients on the ward or in the outpatient clinic.

New Insights into Inflammatory Bowel Disease
  • Language: en
  • Pages: 264

New Insights into Inflammatory Bowel Disease

  • Type: Book
  • -
  • Published: 2016
  • -
  • Publisher: Unknown

The incidence of chronic inflammatory and autoimmune diseases is steadily increasing. Inflammatory bowel disease (IBD) is one example of a chronic inflammatory disease, which primarily affects the intestine but may also affect extraintestinal organs. The exact pathogenesis of IBD is currently unknown. However, it is clear that the pathogenesis is complex, involving barrier defects, changes in the intestinal microbiome, and chronic immune activation. This book aims to summarize basic aspects of these complex interactions between barrier function, microbiome, and the immune system. Of note, there is currently no cure for IBD. However, several therapies have evolved in the last years, which are overall able to-at least temporarily-suppress IBD. These therapies and the underlying mechanism are discussed.

Metallurgical Design and Industry
  • Language: en
  • Pages: 390

Metallurgical Design and Industry

  • Type: Book
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  • Published: 2018-11-19
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  • Publisher: Springer

​This edited volume examines metallurgical technologies and their place in society throughout the centuries. The authors discuss metal alloys and the use of raw mineral resources as well as fabrication of engineered alloys for a variety of applications. The applications covered in depth include financial, mining and smelting, bridges, armor, aircraft, and power generation. The authors detail the multiple levels and scales of impact that metallurgical advances have had and continue to have on society. They include case studies with guidance for future research design and innovation of metallic materials relevant to societal needs. Includes case studies written by industry professionals with guidance for future research design and innovation; Demonstrates metal materials design that reflects relevant societal needs; Covers a broad range of applied materials used in aircraft, armor, bridges, and power generation, among others.

Immunogenetics
  • Language: en
  • Pages: 96

Immunogenetics

  • Type: Book
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  • Published: 2019
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  • Publisher: Unknown

Because genetic factors can impact immune responses, and immunogenetic associations serve as a predictor of disease development and as a biological indicator of disease progression, the study of immunogenetics is important to basic genetics and immunology, as well as to translational and individualized medicine.This book addresses a few but important issues on the subject of immunogenetics. First, it will review the role that human leukocyte antigen molecules play in the immune system and then take into consideration the effectiveness of Western blotting for the detection of immunologic proteins. The book will discuss studies on the immunogenetics of cancer and tuberculosis followed by implications for immunotherapy. Working separately, the book will also provide evidence that the application of immunogenetics has improved our understanding of brain and behavior disorders.

Screening for Colorectal Cancer with Colonoscopy
  • Language: en
  • Pages: 154

Screening for Colorectal Cancer with Colonoscopy

Colorectal cancer remains a major health issue for many developed regions around the world. The good news is that early detection has significantly improved overall survival rates and continues to do so. A number of prevention strategies contribute to this positive trend, and today a patient who undergoes a colonoscopy for screening purposes stands a much better chance of being effectively surveyed for prevention of colorectal cancer. Patients can rely increasingly on the improved datasets and technical advances that are being made in screening approaches and skills. With continued progress, particularly in the partnership between clinicians and computer scientists, the future for colorectal cancer surveillance looks increasingly positive for the development of improved tools and methods.