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A guide to designing lab-based biological experiments that have low bias, high precision and widely applicable results.
Medical nihilism is the view that we should have little confidence in the effectiveness of medical interventions. Jacob Stegenga argues persuasively that this is how we should see modern medicine, and suggests that medical research must be modified, clinical practice should be less aggressive, and regulatory standards should be enhanced.
The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as “assumption controls†and “experimentalist controls†. Furth...
A practical guide to the most important techniques available for longitudinal data analysis, essential for non-statisticians and researchers.
Experimental Aerodynamics provides an up to date study of this key area of aeronautical engineering. The field has undergone significant evolution with the development of 3D techniques, data processing methods, and the conjugation of simultaneous measurements of multiple quantities. Written for undergraduate and graduate students in Aerospace Engineering, the text features chapters by leading experts, with a consistent structure, level, and pedagogical approach. Fundamentals of measurements and recent research developments are introduced, supported by numerous examples, illustrations, and problems. The text will also be of interest to those studying mechanical systems, such as wind turbines.
Regression, analysis of variance, correlation, graphical.
Colorful example-rich introduction to the state-of-the-art for students in data science, as well as researchers and practitioners.
It has been proposed that the brain works in a Bayesian manner, and based on the free-energy principle, the brain's main function is to reduce environmental uncertainty; this is a proposed model as a universal principle governing adaptive brain function and structure. There are many pathophysiological, and clinical observations that can be easily explained by predictive Bayesian brain models. However, the novel applications of Bayesian models in translational neuroscience has been understudied and underreported. For example, variational Bayesian mixed-effects inference has been successfully tested for classification studies. A multi-task Bayesian compressive sensing approach to simultaneously estimate the full posterior of the CSA-ODF and diffusion-weighted volumes from multi-shell HARDI acquisitions has been recently publishe
Artificial Intelligence for Drug Development, Precision Medicine, and Healthcare covers exciting developments at the intersection of computer science and statistics. While much of machine-learning is statistics-based, achievements in deep learning for image and language processing rely on computer science’s use of big data. Aimed at those with a statistical background who want to use their strengths in pursuing AI research, the book: · Covers broad AI topics in drug development, precision medicine, and healthcare. · Elaborates on supervised, unsupervised, reinforcement, and evolutionary learning methods. · Introduces the similarity principle and related AI methods for both big and small...