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First in Fly
A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Stephanie Elizabeth Mohr explains why this tiny insect merits such intense scrutiny, and how laboratory findings made first in flies have expanded our understanding of human health and disease.
First in Fly
A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Why does this tiny insect merit such intense scrutiny? Drosophila's importance as a research organism began with its short life cycle, ability to reproduce in large numbers, and easy-to-see mutant phenotypes. Over time, laboratory investigation revealed surprising similarities between flies and other animals at the level of genes, gene networks, cell interactions, physiology, immunity, and behavior. Like humans, flies learn and remember, fight microbial infection, and slow down as they age. Scientists use Drosophila to investigate complex biological activities in a s...
The Society of Genes
Nearly four decades ago Richard Dawkins published The Selfish Gene, famously reducing humans to “survival machines” whose sole purpose was to preserve “the selfish molecules known as genes.” How these selfish genes work together to construct the organism, however, remained a mystery. Standing atop a wealth of new research, The Society of Genes now provides a vision of how genes cooperate and compete in the struggle for life. Pioneers in the nascent field of systems biology, Itai Yanai and Martin Lercher present a compelling new framework to understand how the human genome evolved and why understanding the interactions among our genes shifts the basic paradigm of modern biology. Contr...
The Genetic Gods
They mastermind our lives, shaping our features, our health, and our behavior, even in the sacrosanct realms of love and sex, religion, aging, and death. Yet we are the ones who house, perpetuate, and give the promise of immortality to these biological agents, our genetic gods. The link between genes and gods is hardly arbitrary, as the distinguished evolutionary geneticist John Avise reveals in this compelling book. In clear, straightforward terms, Avise reviews recent discoveries in molecular biology, evolutionary genetics, and human genetic engineering, and discusses the relevance of these findings to issues of ultimate concern traditionally reserved for mythology, theology, and religious...
Genes in Conflict
In evolution, most genes survive and spread within populations because they increase the ability of their hosts (or their close relatives) to survive and reproduce. But some genes spread in spite of being harmful to the host organism—by distorting their own transmission to the next generation, or by changing how the host behaves toward relatives. As a consequence, different genes in a single organism can have diametrically opposed interests and adaptations.Covering all species from yeast to humans, Genes in Conflict is the first book to tell the story of selfish genetic elements, those continually appearing stretches of DNA that act narrowly to advance their own replication at the expense ...
The Century of the Gene
In a book that promises to change the way we think and talk about genes and genetic determinism, Evelyn Fox Keller, one of our most gifted historians and philosophers of science, provides a powerful, profound analysis of the achievements of genetics and molecular biology in the twentieth century, the century of the gene. Not just a chronicle of biology’s progress from gene to genome in one hundred years, The Century of the Gene also calls our attention to the surprising ways these advances challenge the familiar picture of the gene most of us still entertain. Keller shows us that the very successes that have stirred our imagination have also radically undermined the primacy of the gene—w...
The Triple Helix
One of our most brilliant evolutionary biologists, Richard Lewontin here provides a concise, accessible account of what his work has taught him about biology and about its relevance to human affairs. In the process, he exposes some of the common and troubling misconceptions that misdirect and stall our understanding of biology and evolution.
Lords of the Fly
"One of the most productive of all laboratory animals, Drosophila has been a key tool in genetics research for nearly a century. At the center of Drosophila culture from 1910 to 1940 was the school of Thomas Hunt Morgan and his students Alfred Sturtevant and Calvin Bridges, who, by inbreeding fruit flies, created a model laboratory creature - the 'standard' fly. By examining the material culture and working customs of Morgan's research group, [the author] brings to light essential features of the practice of experimental science. [This book] takes a broad view of experimental work, ranging from how the fly was introducted into the laboratory and how it was physically redesigned for use in genetic mapping, to how the 'Drosophilists' organized an international network for exchanging fly stocks that spread their practices around the world"--Back cover.
Human Gene Therapy
Nichols explores the potential for gene therapy and identifies those who are candidates for it. Having provided a biomedical background for understanding somatic cell gene therapy, she takes a thoughtful look at complex and sensitive issues surrounding ethical, economic, and policy aspects of manipulating human genes.
Atlas of Drosophila Morphology
The Atlas of Drosophila Morphology: Wild-type and Classical Mutants is the guide every Drosophila researcher wished they had when first learning genetic markers, and the tool they wish they had now as a handy reference in their lab research. Previously, scientists had only poor-quality images or sketches to work with, and then scattered resources online - but no single visual resource quickly at their fingertips when explaining markers to new members of the lab, or selecting flies to do their genetic crosses, or hybrids. This alphabetized guide to Drosophila genetic markers lays flat in the lab for easy referencing. It contains high-resolution images of flies and the appropriate marker on th...
