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Melanoma
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Human Skin Cancers
Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.
Holland-Frei Cancer Medicine
Die neueste Ausgabe des Goldstandards in der Krebsforschung und klinischen Onkologie Mit der neu überarbeiteten zehnten Ausgabe von Holland-Frei Cancer Medicine legt ein Team anerkannter Forscher und Ärzte einen umfassenden aktuellen Überblick über die Krebsforschung und die klinische onkologische Praxis vor. Das Werk enthält zeitgemäße und unverzichtbare Informationen aus den Bereichen Epidemiologie, Ätiologie, Krebsbiologie, Immunologie, Prävention, Screening, klinisches Erscheinungsbild, Pathologie, Bildgebung und Therapie. Ausgehend von einem grundlegenden Verständnis der Krebsbiologie stellt Holland-Frei Cancer Medicine eine Verbindung zwischen wissenschaftlichen Prinzipien un...
Science
A weekly record of scientific progress.
Cancer Research
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O Tripulante De Aeronaves E A Radiação Ionizante
A evolução dos transportes aéreos tornou este modal seguro e acessível a um número cada vez maior de pessoas. Porém, novos desafios surgiram, como a exposição à radiação ionizante em altitude e outras fontes de radiações, que podem gerar efeitos somáticos e genéticos, de curto e longo prazo. Esta obra, balizada em mais de uma centena de pesquisas científicas e publicações é uma boa referencia para o estudo do assunto.
The Worldwide Film Noir Tradition
What started as a handful of American crime movies celebrated by French critics after WW II has grown to become the most resonant and enigmatic of all film categories. Since film noir is not a clear-cut, predefined genre like the western or musical, the term has always been open to confusion and dispute. For decades the cultural influence of noir has been expanding. There are now over a hundred books on the subject, numerous guides and reference works. But nothing in print is comprehensive or even close to inclusive of all classic films that deserve to be called noir. The Worldwide Film Noir Tradition is the most far-reaching and definitive reference to classic noir ever produced. The book i...
Epigenetics and Dermatology
Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional ...
Concepts and Case Studies in Chemical Biology
Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years. Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists. With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.
