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Metabolite Safety in Drug Development
A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA. • Reviews the analytical techniques and experimental designs critical for metabolite studies • Covers methods including chirality, species differences, mass spectrometry, radiolabels, and in vitro / in vivo correlation • Discusses target pharmacology, in vitro systems aligned to toxicity tests, and drug-drug interactions • Includes perspectives from authors with firsthand involvement in industry and the study of drug metabolites, including viewpoints that have influenced regulatory guidelines
Salary Book
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The Reality of Linguistic Rules
This volume presents a selection of the best papers from the 21st Annual University of Wisconsin-Milwaukee Linguistics Symposium. Researchers from linguistics, psychology, computer science, and philosophy, using many different methods and focusing on many different facts of language, addressed the question of the existence of linguistic rules. Are such rules best seen as convenient tools for the description of languages, or are rules actually invoked by individual language users? Perhaps the most serious challenge to date to the linguistic rule is the development of connectionist architecture. Indeed, these systems must be viewed as a serious challenge to the foundations of all of contempora...
The Nature and Functions of Gesture in Children's Communication
Imagine a child explaining a conservation judgment by saying, "That one's wider," while indicating the height of a glass with his hand. Now consider an adult saying, "She chased him," while brandishing an imaginary umbrella in her hands. In both of these examples, information different from that conveyed by speech is communicated by movements of the hands. These movements of the hands that co-occur with speech—gestures—are the subject of this volume of the New Directions for Child Development series. Although gesture has always been considered relevant to talk, it has usually been seen as a stream separate from speech, one that can reflect the attitudes and feelings of speakers but that ...
Ann Arbor, Michigan City Directory
Jan. 2003- : "7 directories in 1: section 1: alphabetical section; section 2: business section; section 3: telephone number section; section 4: street guide; section 5: map section; section 6: movers & shakers; section 7: demographic summary."
