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Personalized Medicine in Neuroscience: Molecular to System Approach
Personalized or precision medicine (PM) is developing and adopting of the safest and most cost-effective therapeutic approach for each patient. PM approach aims to identify phenotypic and genotypic individual characteristics, observe how these parameters are correlated with the disease status, severity, and intervention responsiveness to predict the best personalized clinical protocol. On the other hand, the risk of severe toxicity and adverse effects might be related to the patient-specific characteristics.
Douglas DC
Like the P-51 Mustang and Supermarine Spitfire, the Douglas DC-3 is an iconic aircraft design. It has endured more than any other with several hundred still in use worldwide in locations as far apart as Africa, Antarctica and the US. Many of the current operators use turbine conversions of the DC-3mainly using Basler, SAAF and Dodson International the main proponents. Just about every major post-war airline began their schedules with the DC-3. Many took advantage of post-war military surplus C-47s that had already written huge volumes of history with their roles with the US Army Air Corps in the Second World War such as the D-Day landings. Many enthusiast organisations still keep DC-3s airworthy and fly them for members. However, the days of DC-3 operations are now nearing an end thanks to spares unavailability, cost and the shortages of Avgas fuel in remote parts of the world. The Douglas DC-3 is to aviation what the Volkswagen and Ford were to motoring, and what the DC-3 operators started, the 21st century Airbus/Boeing operators continued thanks to the astonishing legacy of this remarkable aircraft. 198 black-and white and 71 colour photographs
Political Parties, Business Groups, and Corruption in Developing Countries
Political corruption is one of the globe's most pressing yet seemingly permanent problems. It is a root cause of low growth and inequality, and plagues numerous nations throughout the world in varying degrees. In Political Parties, Business Groups, and Corruption in Developing Countries, Vineeta Yadav tackles the puzzle of corruption by analyzing the role that business lobbying plays in it. She shows that the structure of a developing nation's legislative institutions frequently determines whether such institutions promote or restrain corruption. Combining focused studies of legislative institutions and business groups in India and Brazil with a broader survey of corruption in sixty four developing democracies, Yadav shows how systems with powerful parties rather than ones with powerful individual legislators encourage the most corruption. A rigorous comparative examination of the connections between political institutions, lobbying, and corruption, this work will reshape our understanding of how developing country democracies can both discourage and encourage bribery, vote buying, and influence peddling.
Understanding the Complex Phenomenon of Suicide: From Research to Clinical Practice
Suicide is undoubtedly a worldwide major challenge for the public health. It is estimated that more than 150,000 persons in Europe die as a result of suicide every year and in several European countries suicide represents the principal cause of death among young people aged 14–25 years. It is true that suicide is a complex (and yet not fully understood) phenomenon and may be determined by the interaction between various factors, such as neurobiology, personal and familiar history, stressful events, sociocultural environment, etc. The suicide is always a plague for the population at risk and one of the most disgraceful events for a human being. Moreover, it implies a lot of pain often share...
Panic Disorder
The book focuses on the neurobiological and treatment aspects of panic disorder. It describes the most recent research data and pharmacological therapeutic aspects of panic disorder. The biochemical, respiratory, imaging, and translational aspects will be together with diagnostic and pharmacological discussion. We have the collaboration of important and recognized researchers from various countries – Brazil, USA, Italy, Spain, United Kingdom, and Switzerland – all of them with a continuous and relevant work on anxiety disorders. "Panic Disorder: Neurobiological and Treatment Aspects" is intended to be a reference book for those who research or treat panic disorder and anxiety disorder patients.
On the Move to Meaningful Internet Systems 2007: OTM 2007 Workshops
This two-volume set LNCS 4805/4806 constitutes the refereed proceedings of 10 international workshops and papers of the OTM Academy Doctoral Consortium held as part of OTM 2007 in Vilamoura, Portugal, in November 2007. The 126 revised full papers presented were carefully reviewed and selected from a total of 241 submissions to the workshops. The first volume begins with 23 additional revised short or poster papers of the OTM 2007 main conferences.
Ferroptosis in Stroke, Neurotrauma and Neurodegeneration, Volume II
This Research Topic is part of the Ferroptosis in Stroke, Neurotrauma and Neurodegeneration series: Ferroptosis in Stroke, Neurotrauma and Neurodegeneration Ferroptosis is a recently defined iron-dependent non-apoptotic form of cell death. Diverse stressors can destabilize metabolic processes in the cell, leading to excessive intracellular accumulation of reactive oxygen species that culminate in the collapse and rupture of the membrane structure of cellular organelles, such as mitochondria, endoplasmic reticulum, and lysosome. Ferroptosis is a form of cell death characterized by the accumulation of intracellular iron and lipid ROS. The primary morphologic manifestations of ferroptosis inclu...
