Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Hypocretins
The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to ob...
Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists
Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice, and the orexin neuron loss associated with human narcoleptic patients laid the foundation for the discovery of small molecul...
Development of Circadian Clock Functions, volume II
The temporal order of physiological functions such as sleep/wakefulness is regulated by the circadian clock. This intrinsic clock starts ticking in the embryo and matures during development, with attenuation of the clock function in the elderly, illustrated by attenuation of synchrony, entrainment, and outputs of cellular circadian rhythms in the SCN. This age-related diminution can contribute to the emergence of diseases, such as sleep disorders, infertility, diabetes, mental disorders etc. Over the course of our lives, a variety of internal and external factors are under the influence of the circadian clock. This inherent developmental plasticity of the circadian system is critical for the...
Neuropeptide GPCRs in neuroendocrinology
The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.
Science Reports
None
Advances in Superconductivity V
This book covers all research fields in high Tc Superconductivity. Breakthrougs in the single crystal growth of a monolithic device leads to a new technology.
Insect Sex Pheromone Research and Beyond
This book provides a complete overview of cutting-edge research on insect sex pheromones and pheromone communication systems. The coverage ranges from the chemistry, biosynthesis, and reception of sex pheromones to the control of odor-source searching behavior, and from molecules to the application of research findings to robotics. The book both summarizes the progress of studies conducted using Bombyx mori and several groups of moths and reviews sex pheromones of some non-lepidopteran insect groups of agricultural importance. Attention is drawn to recent findings on elaborate neural information processing in the brain in male moths and to the importance of olfactory receptors specifically tuned to sex pheromone molecules. Featuring contributions from leading experts on the topic, this book will be a unique and valuable resource for researchers and students in the fields of entomology, chemical ecology, insect physiology and biochemistry, evolution, biomimetics, and bioengineering. In addition to researchers, general insect lovers will find the book fascinating for its descriptions of the marvelous abilities of insects and the underlying mechanisms involved.
