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Phase I Oncology Drug Development
  • Language: en
  • Pages: 352

Phase I Oncology Drug Development

This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicalities in setting up phase I trials. The book covers strategies to accelerate the development of novel antitumor compounds from the laboratory to clinical trials and beyond through the use of innovative mechanism-of-action pharmacodynamic biomarkers and pharmacokinetic studies. The reader will learn about all aspects of modern phase I trial designs, including the incorporation of precision medicine strategies, and approaches for rational patient allocation to novel anticancer therapies. Circulating biomarkers to assess mechanisms of respo...

Targeting the DNA Damage Response for Cancer Therapy
  • Language: en
  • Pages: 333

Targeting the DNA Damage Response for Cancer Therapy

This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.

Reading the Surrey Gardens Tragedy
  • Language: en
  • Pages: 450

Reading the Surrey Gardens Tragedy

  • Type: Book
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  • Published: 2002
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  • Publisher: Unknown

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Medical Image Understanding and Analysis
  • Language: en
  • Pages: 471

Medical Image Understanding and Analysis

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Medical Image Understanding and Analysis
  • Language: en
  • Pages: 435

Medical Image Understanding and Analysis

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Sentimentality and Post-gay Identity
  • Language: en
  • Pages: 270

Sentimentality and Post-gay Identity

  • Type: Book
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  • Published: 1997
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  • Publisher: Unknown

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Gynaecological Cancers
  • Language: en
  • Pages: 273

Gynaecological Cancers

  • Type: Book
  • -
  • Published: 2011-06
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  • Publisher: RCOG

This book provides comprehensive coverage of gynaecological malignancies based on the 60th RCOG Study Group.

Medical Image Understanding and Analysis
  • Language: en

Medical Image Understanding and Analysis

  • Type: Book
  • -
  • Published: 2024-07-24
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  • Publisher: Springer

This two-volume set LNCS 14859-14860 constitutes the proceedings of the 28th Annual Conference on Medical Image Understanding and Analysis, MIUA 2024, held in Manchester, UK, during July 24–26, 2024. The 59 full papers included in this book were carefully reviewed and selected from 93 submissions. They were organized in topical sections as follows: Part I : Advancement in Brain Imaging; Medical Images and Computational Models; and Digital Pathology, Histology and Microscopic Imaging. Part II : Dental and Bone Imaging; Enhancing Low-Quality Medical Images; Domain Adaptation and Generalisation; and Dermatology, Cardiac Imaging and Other Medical Imaging.

Medical Image Understanding and Analysis
  • Language: en

Medical Image Understanding and Analysis

  • Type: Book
  • -
  • Published: 2024-07-24
  • -
  • Publisher: Springer

This two-volume set LNCS 14859-14860 constitutes the proceedings of the 28th Annual Conference on Medical Image Understanding and Analysis, MIUA 2024, held in Manchester, UK, during July 24–26, 2024. The 59 full papers included in this book were carefully reviewed and selected from 93 submissions. They were organized in topical sections as follows: Part I : Advancement in Brain Imaging; Medical Images and Computational Models; and Digital Pathology, Histology and Microscopic Imaging. Part II : Dental and Bone Imaging; Enhancing Low-Quality Medical Images; Domain Adaptation and Generalisation; and Dermatology, Cardiac Imaging and Other Medical Imaging.

Emerging Therapeutic Targets in Ovarian Cancer
  • Language: en
  • Pages: 299

Emerging Therapeutic Targets in Ovarian Cancer

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