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Justice Ends at Home and Warner & Wife
ustice Ends at Home was originally published in the Pulp magazine All-Story Weekly. It is both a legal thriller and a detective story. All scholars of Stout's work agree that its main characters, the phlegmatic, middle-aged Simon Leg and his youthful assistant Dan Culp, are Nero Wolfe and Archie Goodwin already living, perhaps subconsiouly, in the mind of Rex Stout eighteen years before Fer-de-Lance was written. Warner & Wife was originally published in January 30, 1915 issue of the Pulp magazine All-Story Cavalier Weekly. It is sort of a legal thriller, the story of a partnership fifteen years in the making. This is one of the novella length stories written by Rex Stout for the Pulps almost two decades before Nero Wolfe and Archie Goodwin were born.
Endothelin and Its Inhibitors
Recent publications have addressed specific aspects of the endothelins, such as their roles in disease or the importance of endothelin receptors. However, in this book the entire field of endothelins is covered. This includes the pathways of endothelin production and their regulation, the local and systemic actions of endothelins, receptors for the endothelins and the signalling pathways employed, and the involvement of endothelins in a range of diseases. Attention is also paid to the development through chemistry, pharmacology and toxicology of endothelin antagonists and endothelin-converting enzyme inhibitors, with mention of all the important members of these drug classes. This leads to well-rounded discussions of the potential therapeutic benefit of endothelin inhibitors.
Target Practice
An invaluable sample of the early work of one of America’s finest mystery writers Decades before detective Nero Wolfe and his sidekick, Archie Goodwin, first struck fear into the hearts of Manhattan’s criminals, Rex Stout wrote fiction for All-Stories Magazine. By the time the Wolfe series brought him fame, Stout had put his early work behind him, and made no effort to preserve it. At the time of his death, these early mysteries and suspense stories were thought to be lost forever, but deep in the Library of Congress lay copies of the original magazine. Published for the first time in 1997, these early gems show a writer deploying all the humor, style, and clever plotting that would make Nero Wolfe a star. Included here are “Secrets,” Stout’s first mystery, “Target Practice,” a story of World War I, and “Justice Ends at Home,” whose main characters will look very familiar to fans of Nero and Archie.
Endothelins in Biology and Medicine
Endothelin-1 (ET-1), a peptide discovered in 1988, is one of the most potent contractors of vascular smooth muscle. Since their discovery, ETs have generated enormous interest in the scientific and pharmaceutical communities, prompting extensive research. This book addresses the latest findings regarding ETs-how they function, their effects, and characteristics. Divided into five sections, the book covers: endothelin receptors, endothelin synthesis and degradation, endothelin pathophysiology, ligand structure and activity relationships, and clinical studies. Pharmacologists, toxicologists, and pharmaceutical researchers will all benefit from this thorough review of current findings and future directions in ET research.
Cytokines in Severe Sepsis and Septic Shock
t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tec...
COX-2 Inhibitors
COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.
Recent Advances in Anaesthesia and Intensive Care: Volume 22
Recent Advances in Anaesthesia and Intensive Care 22 is the latest volume in this very successful and long-established series (previously entitled Recent Advances in Anaesthesia and Analgesia) to present a series of cutting-edge topics for anaesthetists from some of the world's leading authorities in their subjects. As the title suggests, this and future volumes will have increased input from the field of intensive care, but the emphasis will remain on producing articles of high quality and interest to the reader and providing exceptional value for money.
Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s
This volume arose from the scientific program of the XIIth International Congress of Pharmacology, held in Montreal, Canada, July 24-29, 1994. The scientific program included plenary lectures and symposia, in addition to poster presentations and colloquia. The abstracts of the Congress presentations were published as .supplement 1 of volume 72 by the Cana dian Journal of Physiology & Pharmacology. The Congress organizers sought a more expansive treatment of the Congress proceedings and appointed Dr. A. Claudio Cuello to coordinate preparation of the present volume; Dr. Brian Collier was chair of the scientific program committee and, thus, also collaborated on this work. The objective that we...
Genealogy of the Bridgman Family
James Bridgman was born in England, came to America in 1640 and lived in Hartford, Conn. and Northampton, Mass.
