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Justice Ends at Home and Warner & Wife
ustice Ends at Home was originally published in the Pulp magazine All-Story Weekly. It is both a legal thriller and a detective story. All scholars of Stout's work agree that its main characters, the phlegmatic, middle-aged Simon Leg and his youthful assistant Dan Culp, are Nero Wolfe and Archie Goodwin already living, perhaps subconsiouly, in the mind of Rex Stout eighteen years before Fer-de-Lance was written. Warner & Wife was originally published in January 30, 1915 issue of the Pulp magazine All-Story Cavalier Weekly. It is sort of a legal thriller, the story of a partnership fifteen years in the making. This is one of the novella length stories written by Rex Stout for the Pulps almost two decades before Nero Wolfe and Archie Goodwin were born.
Endothelins in Biology and Medicine
Endothelin-1 (ET-1), a peptide discovered in 1988, is one of the most potent contractors of vascular smooth muscle. Since their discovery, ETs have generated enormous interest in the scientific and pharmaceutical communities, prompting extensive research. This book addresses the latest findings regarding ETs-how they function, their effects, and characteristics. Divided into five sections, the book covers: endothelin receptors, endothelin synthesis and degradation, endothelin pathophysiology, ligand structure and activity relationships, and clinical studies. Pharmacologists, toxicologists, and pharmaceutical researchers will all benefit from this thorough review of current findings and future directions in ET research.
Winning the Crowd
How are the films we watch shaping our political worldview? Studies show that films shape us—they affect our values, our beliefs, and our actions. Consequently understanding the messages reinforced by many popular films is vital for everyone, and especially for the student of politics. Winning The Crowd: The Politics of Popular Films showcases careful, close readings of recent, popular films as serious texts of political thought. Ten contributors select a film or small set of related films—from the John Wick franchise to Pixar's The Incredibles—and analyze the political orientations that these films convey. The volume will be a helpful introduction for those interested in what Hollywood is teaching its viewers about power and the good life. It will also be a valuable model for those wishing to sharpen their own ability to think critically about the meaning of their evening entertainment. How have your values and beliefs been formed by Hollywood? Winning The Crowd takes you on a guided journey through some of the smartest popular films of recent years.
Cytokines in Severe Sepsis and Septic Shock
t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tec...
COX-2 Inhibitors
COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.
Cyclic GMP: Synthesis, Metabolism, and Function
This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messengers such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are also discussed. The last chapter raises many important questions in the field that remain to be addressed. - Isoforms of guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis - Cyclic GMP-dependent protein kinase - Hormones and ligands that regulate GMP formation and/or metabolism - Effects of cyclic GMP on other second messengers and some functions such as smooth muscle relaxation and ion transport - Clinical studies with cyclic GMP and atrial natriuretic peptide - Important questions and experiments for the future
Sildenafil
Sildenafil, for the treatment of erectile dysfunction, is one of the first products that has made its way successfully from basic NO (nitrous oxide) research, to clinical routine therapy. Sidenafil, part of the Milestones in Drug Therapy series, presents the major breakthroughs in the field of NO physiology and pharmacology that led to the development of the drug, as well as clinical applications in one source guide. Written by leading experts in the field, each chapter covers aspects of clinical use and experience, pharmacokinetics, pharmacodynamics, biochemistry, and cultural science.
Biochemistry, Molecular Biology, and Therapeutic Implications
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types. - Presents comprehensive coverage of the chemical properties of nitric oxide and how they form the basis for the multifaceted biological actions for nitric oxide - Contains the most current and detailed documentation of the properties and regulation of nitric oxide synthases - Provides the most up-to-date review of inhalational nitric oxide therapy for treatment of respiratory dysfunction
The Red Book
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Crescent City Marine
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