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"Son of Man"
Who is the “Son of Man”? In pre-Christian Jewish writings, “Son of Man” was not a title, and it certainly did not indicate divinity. It was simply an expression for a man. Yet the term has held considerable interest among scholars of Christology for its use in describing Jesus in the gospels. And among those studying messianism in Second Temple Judaism, consensus about the valences of “Son of Man” in Scripture remains elusive. In the first volume of this landmark study, Richard Bauckham pushes the conversation forward, explicating the phrase “Son of Man” as it appears in Jewish interpretations of the book of Daniel and in the apocryphal book of 1 Enoch. With philological precision and sensitivity to his sources, Bauckham attunes us to the realities of early Jewish eschatology. Thorough and comprehensive, “Son of Man,” vol. 1, offers scholars a solid basis for understanding the context of the messiah in the centuries leading up to Jesus. Along with the forthcoming second volume, which parses the meaning of “Son of Man” in the Gospels, Bauckham’s work is essential for understanding one of the most widely used yet misunderstood phrases in the Bible.
Hearing the Old Testament in the New Testament
How does the New Testament echo the Old? Which versions of the Hebrew Scriptures were authoritative for New Testament writers? The appearance of concepts, images, and passages from the Old Testament in the books of the New raises important questions about textual versions, allusions, and the differences between ancient and modern meaning. Written by ten distinguished scholars, Hearing the Old Testament in the New Testament first lays out significant foundational issues and then systematically investigates the use of the Old in the New Testament. In a culminating essay Andreas Kstenberger both questions and affirms the other contributors' findings. These essays together will reward a wide range of New Testament readers with a wealth of insights.
General Principles of Tumor Immunotherapy
This book brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.
Camptothecins in Cancer Therapy
A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.
The Use of the Septuagint in New Testament Research
Too often the Septuagint is misunderstood or, worse, ignored in New Testament studies. In this book R. Timothy McLay makes a sustained argument for the influence of the Greek Jewish Scriptures on the New Testament and offers basic principles for bridging the research gap between these two critical texts. McLay explains the use of the Septuagint in the New Testament by looking in depth at actual New Testament citations of the Jewish Scriptures. This work reveals the true extent of the Septuagint s impact on the text and theology of the New Testament. Indeed, given the textual diversity that existed during the first century, the Jewish Scriptures as they were known, read, and interpreted in the Greek language provided the basis for much, if not most, of the interpretive context of the New Testament writers. Complete with English translations, a glossary of terms, an extensive bibliography, and helpful indexes, this book will give readers a new appreciation of the Septuagint as an important tool for interpreting the New Testament.
Cancer Drug Resistance
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Death Receptors in Cancer Therapy
An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.
The Oncogenomics Handbook
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Tumor Immunology and Cancer Vaccines
- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field
Combination Cancer Therapy
Expert physician-scientists and clinicians review those combinations of novel target agents classic chemotherapies that hold the most promise for the future of medical oncology, and detail their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatments in cancer therapy.
