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Glycogen synthase kinase 3β: the nexus of chemoresistance, invasive capacity, and cancer stemness in pancreatic cancer
The treatment of pancreatic cancer remains a significant clinical challenge due to the limited number of patients eligible for curative (R0) surgery, failures in the clinical development of targeted and immune therapies, and the pervasive acquisition of chemotherapeutic resistance. Refractory pancreatic cancer is typified by high invasiveness and resistance to therapy, with both attributes related to tumor cell stemness. These malignant characteristics mutually enhance each other, leading to rapid cancer progression. Over the past two decades, numerous studies have produced evidence of the pivotal role of glycogen synthase kinase (GSK)3β in the progression of over 25 different cancer types,...
Essentials and Controversies in Bariatric Surgery
Bariatric surgery has been proved to be clinically effective and economically viable for obese people when compared to non-surgical interventions. Advancement of minimally invasive surgery in the last 20 years has made the safety and reliability widely accepted by the public and government systems. Bariatric surgery not only proves its efficacy in marked long-term weight loss, but also aids in achieving substantial improvement or remission of co-morbidities. In this book, we review the fundamental knowledge of bariatric surgery, including preoperative nutrition, selection, and surgical complication. In the second part, new emerging and novel procedures are thoroughly described and discussed. Unquestionably, this book will offer you essentials as well as the latest concepts of bariatric and metabolic surgery.
Hitachi Technology
Beginning with the issue of Vol. 47, No. 2 (April 1998), the full-page edition of Hitachi Review has been available only on...web page in place of the conventional publication.
Annual Meeting
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Hitachi Review
Beginning with the issue of Vol. 47, No. 2 (April 1998), the full-page edition of Hitachi Review has been available only on...web page in place of the conventional publication.
I-THERM IV
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The Engineering Index Annual
Since its creation in 1884, Engineering Index has covered virtually every major engineering innovation from around the world. It serves as the historical record of virtually every major engineering innovation of the 20th century. Recent content is a vital resource for current awareness, new production information, technological forecasting and competitive intelligence. The world?s most comprehensive interdisciplinary engineering database, Engineering Index contains over 10.7 million records. Each year, over 500,000 new abstracts are added from over 5,000 scholarly journals, trade magazines, and conference proceedings. Coverage spans over 175 engineering disciplines from over 80 countries. Updated weekly.
