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Molecular Toxinology has been consolidated as a scientific area focused on the intertwined description of several aspects of animal toxins. In an inquiring biotechnological world, animal toxins appear as an invaluable source for the discovery of therapeutic polypeptides. Animal toxins rely on specific chemical interactions with their partner molecule to exert their biological actions. The comprehension of how molecules interact and recognize their target is essential for the rational exploration of bioactive polypeptides as therapeutics. Investigation on the mechanism of molecular interaction and recognition offers a window of opportunity for the pharmaceutical industry and clinical medicine. Thus, this book brings examples of two interconnected themes - molecular recognition and toxinology concerning to the integration between analytical procedures and biomedical applications.
Amyloidoses are a heterogeneous group of diverse etiology diseases. They are characterized by an endogenous production of abnormal proteins called amyloid proteins, which are not hydrosoluble, form depots in various organs and tissue of animals and humans and cause dysfunctions. Despite many decades of research, the origin of the pathogenesis and the molecular determinants involved in amyloid diseases has remained elusive. At present, there is not an effective treatment to prevent protein misfolding in these amyloid diseases. The aim of this book is to present an overview of different aspects of amyloidoses from basic mechanisms and diagnosis to latest advancements in treatment.
This book constitutes the refereed proceedings of the 9th International Conference on Cooperative Design, Visualization, and Engineering, CDVE 2012, held in Osaka, Japan, in September 2012. The 36 revised full papers presented were carefully reviewed and selected from numerous submissions. The papers cover the topics of cooperative engineering, basic theories, methods and technologies that support CDVE, cooperative design, visualization and applications.
Future Cities For the first time in human history, more than 50% of the world's population lives in urban regions. Cities are the largest, most complex, and most dynamic man-made systems. They are vibrant centers of cultural life and engines that drive the global economy. Contemporary cities are environmentally, socially, and economically unsustainable. The quality of urban life is threatened by such factors as pollution, rising temperatures, limited resources, congestion, social inequalities, aging of large sectors of the world population, poverty, informality, crime, and economic imbalances. The overall planning of future cities is a challenge that can only be faced by interdisciplinary te...
This book constitutes the refereed proceedings of the 15th International Conference on Computer-Aided Architectural Design Futures, CAAD Futures 2013, held in Shanghai, China, in July 2013. The 35 revised full papers presented were carefully reviewed and selected from 78 submissions. The papers are organized in topical sections on digital aids to design creativity, concepts, and strategies; digital fabrication and local materialization; human-computer interaction, user participation, and collaborative design; modeling and simulation; shape and form studies.
Internationally refereed papers present the state of the art in computer-aided architectural design research. These papers reflect the theme of the 12th International Conference of CAADFutures, Integrating Technologies for Computer-Aided Design. Collectively, they provide the technological foundation for new ways of thinking about using computers to design. In addition, they address the education of designers themselves.
This book presents cutting-edge surgical techniques and the new operating rooms supporting them, as well as their future developments. In recent years, with the advances in surgical medicine, surgical techniques have undergone great changes. However, safety and reliability are still the major requirements of the operating room, and these are closely linked to the patients’ wellbeing. The new medical instruments and medical materials being developed to perform surgery more safely, reliably and efficiently are vital technologies supporting this. “New techniques” involve the introduction of innovative medical instruments and medical materials, and these, too, are increasing in terms of performance and size every year. Surgery and Operating Room Innovation discusses these issues from the perspective of various professionals involved with operating rooms.
The two-volume set LNCS 8618 and 8619 constitutes the refereed proceedings of the 9th International Conference EuroHaptics 2014, held in Versailles, France, in June 2014. The 118 papers (36 oral presentations and 82 poster presentations) presented were carefully reviewed and selected from 183 submissions. Furthermore, 27 demos were exhibited, each of them resulting in a short paper included in the volumes. These proceedings reflect the multidisciplinary nature of EuroHaptics and cover topics such as human-computer interaction, human-robot interactions, neuroscience, perception and psychophysics, biomechanics and motor control, modelling and simulation; and a broad range of applications in medicine, rehabilitation, art, and design.