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Computational and Experimental Protein Variant Interpretation in the Era of Precision Medicine
One of the key goals in the postgenomic era is the elucidation of the mechanisms underlying the relationship between genotype and phenotype. In particular, understanding how human genetic and somatic variations are associated with diseases is still an open problem and its solution is a crucial issue for exploiting the possibilities offered by the modern sequencing techniques in the framework of precision and personalized medicine. The increasing amount of data generated by the sequencing initiatives calls for accurate and reliable computational approaches to predict the impact of mutations on the phenotype, and possibly for methods to correlate them with diseases. From the experimental point of view, disease-causing variants are supposed to directly affect protein function, protein stability as well as the kinetics and thermodynamics of protein-protein recognition, and robust validation at the molecular scale is necessary. This approach can be of invaluable help in facing new challenges such as the fast development of effective vaccines.
Chemical Abstracts
None
Biography and Genealogy Master Index
Comprehensive index to current and retrospective biographical dictionaries and who's whos. Includes biographies on over 3 million people from the beginning of time through the present. It indexes current, readily available reference sources, as well as the most important retrospective and general works that cover both contemporary and historical figures.
Guida Monaci
None
The Basilica of Saint John Lateran to 1600
The first inter-disciplinary study to examine the construction and development of the world's first cathedral from its origins to 1600.
