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Acute Renal Failure
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The Treatment of Glomerulonephritis
Glomerulonephritis is one of the commonest causes of end-stage renal failure worldwide. Although there have been considerable advances in the management of renal failure by dialysis and transplantation, there has been relatively little progress in its prevention. This volume sets out to review current practice in the treatment of glomerulonephritis, which is aimed both at controlling the clinical manifestations, e.g. nephrotic syndrome, and at preventing the progression to renal failure. The term glomerulonephritis covers a wide range of conditions with different immunological, histological and clinical features. This volume therefore starts with reviews of the immunology and pathology of di...
The Kidney and Hypertension in Diabetes Mellitus
The first sporadic observations describing renal abnormalities in diabetes were published late in the 19th century, but systematic studies of the kidney in diabetes started only half a century ago after the paper by Cambier in 1934 and the much more famous study by Kimmelstiel and Wilson in 1936. These authors described two distinct features of renal involvement in diabetes: early hyperfiltration and late nephropathy. Diabetic nephropathy is, despite half a century of studies, still a very pertinent problem, renal disease in diabetes now being a very common cause of end-stage renal failure in Europe and North America and probably throughout the world. It is a very important part of the gener...
Inheritance of Kidney and Urinary Tract Diseases
Genetic disorders have emerged as a prominent cause of morbidity and mor tality among infants and adults. As many as 10% to 20% of hospital admis sions and at least 10% of the mortality in this age group are due to inherited diseases. There are at least two factors that have brought genetic disorders into the forefront of pediatrics. One is a great reduction in childhood mortality due to infections and nutritional deficiency states, and the other is the rapid progress made in the identification of genetic defects. Amniocentesis, chorionic villus sampling, and recombinant DNA technology have already had a tremendous impact on the practice of medicine. This is why the first two chapters of thi...
Nephrology and Urology in the Aged Patient
The master tool of logic is the syllogism. If A> Band B> C, then it must follow as the night the day that A > C. If the major and minor premises are true or scientifically correct by current knowledge, the conclusion is true or at least scientifically correct by current knowledge. The demographer of today beams a clear message, which if not true is at least scientifically correct by current knowledge. In the first 80 years of the Twentieth Century, the 'over-65' population of Americans increased eight fold. By century's end it will have increased 12-fold and shortly thereafter will include one in five Americans. While initially a fact of the developed world, the pace of similar graying is ac...
Critical Care Nephrology
Internists, surgeons, critical care physicians and nephrologists all treat critically ill patients with renal failure and the multiple system organ dysfunction syndrome. A comprehensive review of the state of the art of this topic is definitely needed both in academic and clinical medicine, and Critical Care Nephrology fulfils this need. It is a useful reference tool for both nephrologists and intensive care specialists and it is therefore no coincidence that the editors of the book are themselves specialists in these particular fields. The book addresses the following: definitions of critical illness, epidemiology, monitoring and diagnostic procedures, pathophysiology of organ systems in re...
Methods in Renal Toxicology
The only up-to-date compilation of renal methods available, this book is the definitive resource for any renal researcher eager to stay ahead. Methods in Renal Toxicology presents a vast array of methods for the study of renal cellular and tubular structure, function, and biochemistry under physiological, toxicological, and pathological conditions. It provides detailed descriptions in easy-to-understand language of methods designed to enhance your research efforts. Methods in Renal Toxicology puts you on the cutting edge with valuable chapters detailing molecular methods and transgene and gene targeting - the most recent approaches to the study of renal toxicology. Overall, the book's topics...
Renal Physiology
This new section of the Handbook of Physiology provides a comprehensive and authoritative account of current knowledge about kidney function. The early chapters emphasize structure, and relationships between structure and function. Tissue culture and renal micropuncture are among the many techniques discussed in detail. The physiology of non-renal tissues that serve as models of tubule function, comparative physiology, and developmental aspects of kidney function are similarly discussed. Glomerular filtration and mechanisms of transport of different solutes in water at the level of plasma membranes, of renal tubules, and of the whole kidney are covered in depth. The concentrating mechanism, ...
