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Studies in Natural Products Chemistry
Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up to the pharmaceutical industry exciting opportunities in the field of new drug development. The series covers all of the above as well as the synthesis, testing and recording of the medicinal properties of natural products. - Describes the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - A valuable source for researchers in natural product and medicinal chemistry
Studies in Natural Products Chemistry
Chalcones are a group of plant-derived polyphenolic compounds that possess a wide variety of biological activities. Several lead compounds with various pharmacological properties have been developed based on the chalcone skeleton. The beneficial effect of these substances has been studied in relation to diabetes mellitus. Several studies have demonstrated that chalcones either from natural or synthetic sources can influence carbohydrate pathways, especially glucose metabolism. These studies verified the effectiveness of chalcones as antihyperglycemic and/or hypoglycemic agents through in vitro and in vivo experimental responses. In this context, these molecules are attractive substances whic...
Handbook of Research on Advancing Health Education through Technology
The Internet serves as an essential tool in promoting health awareness through the circulation of important research among the medical professional community. While digital tools and technologies have greatly improved healthcare, challenges are still prevalent among diverse populations worldwide. The Handbook of Research on Advancing Health Education through Technology presents a comprehensive discussion of health knowledge equity and the importance of the digital age in providing life-saving data for diagnosis and treatment of diverse populations with limited resources. Featuring timely, research-based chapters across a broad spectrum of topic areas including, but not limited to, online health information resources, data management and analysis, and knowledge accessibility, this publication is an essential reference source for researchers, academicians, medical professionals, and upper level students interested in the advancement and dissemination of medical knowledge.
The Republican Alternative
The Republican Alternative seeks to move beyond the mere notion of scholarly inquiry into the republic—the subject of recent rediscovery by political historians interested in Europe’s intellectual heritage—by investigating the practical similarities and differences between two early modern republics, as well as their self-images and interactions during the turbulent seventeenth and eighteenth centuries. Among the world’s most economically successful societies, Switzerland and the Netherlands laid much of the foundation for their prosperity during the early modern period discussed here. This volume attempts to clarify the special character of these two countries as they developed, including issues of religious plurality, the republican form of government, and an increasingly commercially-driven agrarian society.
Studies in Natural Products Chemistry
Lichens are fascinating symbiotic organisms, biosynthesizing a broad spectrum of interesting secondary metabolites and polysaccharides. A considerable number of them have been found to exert biological activities, such as antibiotic, antimycobacterial, antiviral, anti-inflammatory, analgesic, antipyretic, antiproliferative, and cytotoxic effects. Only a very low percentage of “lichen substances” have been actually screened for their biological activities and their potential therapeutic applications in medicine. This is due to difficulties to obtain large quantities of lichens from nature, isolated lichen fungi and algae from cultures for extractions. Ten years ago, we have started to byp...
Handbook of Critical Care Nephrology
Designed specifically for nephrologists and trainees practicing in the ICU, Handbook of Critical Care Nephrology is a portable critical care reference with a unique and practical nephrology focus. Full-color illustrations, numerous algorithms, and intuitively arranged contents make this manual a must-have resource for nephrology in today’s ICU.
AMP-Activated Protein Kinase Signalling
Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in hu...
The Early Horn
A guide to eighteenth and nineteenth century performance practice on the horn.
Recent Advances in Polyphenol Research, Volume 3
Plant polyphenols are secondary metabolites that constitute one of the most common and widespread groups of natural products. They express a large and diverse panel of biological activities including beneficial effects on both plants and humans. Many polyphenols, from their structurally simplest representatives to their oligo/polymeric versions (also referred to as vegetable tannins) are notably known as phytoestrogens, plant pigments, potent antioxidants, and protein interacting agents. Sponsored by Groupe Polyphénols, this publication, which is the third volume in this highly regarded Recent Advances in Polyphenol Research series, is edited by Véronique Cheynier, Pascale Sarni-Manchado, ...
European Surgical Orthopaedics and Traumatology
This important reference textbook covers the surgical management of all major orthopaedic and traumatological conditions. The book will act as the major source of education and guidance in surgical practice for surgeons and trainees, especially those preparing for higher surgical examinations and the Board of Orthopaedics and Traumatology examinations within and beyond Europe. The emphasis throughout is on the application of current knowledge and research to technical problems, how to avoid operative problems, and how to salvage complications if they occur. The didactic text is complemented by abundant illustrations that highlight the essentials of each clinical scenario. The authors are all recognized international authorities active at congresses and workshops as well as in universities and hospitals across the world.
