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Studies in Natural Products Chemistry
Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up to the pharmaceutical industry exciting opportunities in the field of new drug development. The series covers all of the above as well as the synthesis, testing and recording of the medicinal properties of natural products. - Describes the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - A valuable source for researchers in natural product and medicinal chemistry
Studies in Natural Products Chemistry
Chalcones are a group of plant-derived polyphenolic compounds that possess a wide variety of biological activities. Several lead compounds with various pharmacological properties have been developed based on the chalcone skeleton. The beneficial effect of these substances has been studied in relation to diabetes mellitus. Several studies have demonstrated that chalcones either from natural or synthetic sources can influence carbohydrate pathways, especially glucose metabolism. These studies verified the effectiveness of chalcones as antihyperglycemic and/or hypoglycemic agents through in vitro and in vivo experimental responses. In this context, these molecules are attractive substances whic...
Intraoperative Monitoring
In recent decades, the advances in and consolidation of Intraoperative Neurophysiological Monitoring (IOM) in several highly complex surgical areas have been undeniable. Currently all modalities of neurophysiological tests (SSEP, MEP, EMG, PEATC, VEP, BRAIN MAPPING, ETC) are performed in the operating room, where they are used to provide trans operative information on the patient’s neurological status in real time (monitoring), and to identify neural structures which are at immediate risk (mapping). With the inarguably positive impact of IOM on surgical outcomes, there is an increasing interest in reliable, technically focused literature. This volume provides cutting-edge information in th...
Three Centuries of Conflict in East Timor
Introduction : situating recurrent mass violenceContested origins -- Maubara and the Dutch East India Company -- Vassalage and violence, 1861-1887 -- The uprising and devastation of 1893 -- High colonialism and new forms of oppression, 1894-1974 -- The end of empire and the Indonesian occupation, 1974-1998 -- Serious crimes and the politics of the past, 1999-2012.
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DIREITO COLETIVO DO TRABALHO ESTUDOS EM HOMENAGEM AO PROFESSOR RICARDO JOSÉ MACÊDO DE BRITTO PEREIRA
Esta obra coletiva, organizada pelas jovens e brilhantes operadoras do Direito que integram o programa do Mestrado em Direito das Relações Sociais e Trabalhistas do Centro Universitário do Distrito Federal – UDF Daniela de Morais do Monte Varandas, Denise Arantes Santos Vasconcelos e Paula Duarte Tavares Rodrigues, a primeira delas Procuradora do Trabalho e as demais atuantes advogadas trabalhistas, é lançada em momento muito oportuno da vida nacional.
Metáforas do Conhecimento
Como podemos falar do que ainda não conhecemos? Como falar aos outros do que conhecemos e eles ainda não conhecem? Pouco mais podemos fazer que partir de uma metáfora. Uma comparação concentrada numa imagem: "é como se...". A é B. Por isso, é tão importante pensar nas metáforas que escolhemos. Para falar do que estamos a conhecer ou do que queremos que os outros conheçam: a árvore, a maçã, a lua, a caverna, a montanha, a pirâmide, a viagem, o barco... Fazemos aqui essa reflexão a partir de autores e textos concretos. A Literatura Comparada liberta-se hoje das relações dogmáticas de influenciadores e influenciados para se tornar mais legível através de uma metáfora: a Literatura-Mundo.
