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This second edition provides new and updated methods and protocols for studying tumor angiogenesis in vitro and in vivo. Chapters detail morphological aspects of tumor angiogenesis, aortic ring, ex vivo tissue culture model for anti-angiogenic drug testing, transgenic zebrafish, orthotopic models of ovarian cancer, and uncovering metabolic effects of anti-angiogenic therapy in tumors by induced metabolic bioluminescence imaging.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Tumor Angiogenesis Assays: Methods and Protocols, Second Edition is a valuable resource for all researchers interested in learning more about this important and developing field.
This book provides a comprehensive review of the epidemiology, pathogenesis, diagnosis, and management of chordomas of the mobile spine and sacrum. Historically, knowledge about how to deliver such state-of-the-art care has not been widespread, resulting in inconsistent treatment, and, all too often, suboptimal outcomes for chordoma patients. This text is an important step towards broadening that knowledge, and, in turn, improving the care provided to chordoma patients. The book is divided into 4 parts comprising 16 chapters. The first part focuses on the pathophysiology and molecular drivers of chordoma. The second focuses on the epidemiology and clinical history, as well as the histologica...
This book provides pregnant women and new parents with evidence-based information on pregnancy and parenting. Most parenting books advise pregnant women or new parents what to do and, at best, defend that advice by citing recommendations from highly selected “experts” or equally selective “studies.” Some parents prefer an advice book, but an increasing number do not trust the advice they receive unless they are convinced of its scientific backing. Dr. Kramer does not tell pregnant women or new parents what they should or should not do. Instead, he focuses on controversial decision choices for which recommendations and practices differ substantially. He systematically reviews and synt...
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Video Atlas of Neurosurgery: Contemporary Tumor and Skull Base Surgery is a unique resource that consists of 40 procedural videos and a concise companion book to reinforce your understanding of the material. Dr. Alfredo Quiñones-Hinojosa brings together a group of outstanding faculty, residents, and fellows lead by Dr. Jordina Rincon-Torroella, who carefully designed, assembled, and edited each chapter. The videos are enhanced through the inclusion of intraoperative photos, anatomical dissections, outstanding anatomical drawings, and animations that detail key steps and provide the experience of viewing a real-time surgery. Whether consulted together or independently of each other, the vide...
Class-tested and coherent, this textbook teaches classical and web information retrieval, including web search and the related areas of text classification and text clustering from basic concepts. It gives an up-to-date treatment of all aspects of the design and implementation of systems for gathering, indexing, and searching documents; methods for evaluating systems; and an introduction to the use of machine learning methods on text collections. All the important ideas are explained using examples and figures, making it perfect for introductory courses in information retrieval for advanced undergraduates and graduate students in computer science. Based on feedback from extensive classroom experience, the book has been carefully structured in order to make teaching more natural and effective. Slides and additional exercises (with solutions for lecturers) are also available through the book's supporting website to help course instructors prepare their lectures.
Este livro faz parte dos primeiros lançamentos da Editora Amplla e tem como título “Meio ambiente e sociedade: análises, diálogos e conflitos ambientais”. As temáticas que são abordadas ao longo dos capítulos tratam da relação indissociável entre sociedade e meio ambiente, sob o enfoque do desenvolvimento sustentável, poluição, saneamento ambiental, saneamento básico, educação ambiental, preservação de recursos naturais, conflitos ambientais e recuperação de áreas degradadas.
O livro ESCRITAS AUTOBIOGRÁFICAS SOBRE ENSINO, PESQUISA E FORMAÇÃO DE PROFESSORES(AS), se compõe de uma pluralidade de textos escritos por professores(as) pesquisadores(as) narradores(as), de diferentes regiões e instituições do país, fruto do diálogo com escola-universidade e outros contextos educativos, formativos e pedagógicos. Trata-se de uma obra na qual apresenta a riqueza e beleza de múltiplas experiências instituintes e vozes equipolentes, construída coletivamente com ética, estética, sensibilidade e afetação se transmutando em modos diversos de dizer e contar de si com o(a) outro(a) em escritas narrativas e (auto)biográficas no campo da educação e outras áreas do conhecimento.