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The Diabetic Pancreas
Since the publication of the first edition of The Diabetic Pancreas in 1977, much progress has been made in various areas of diabetes research. While only a rela tively short while ago diabetes was considered a single disease, in more recent years it has become apparent that it is a heterogeneous group of disorders, all of which are characterized by a decreased tolerance of carbohydrates and most of which have a genetic basis, although the genetic types vary. In more recent years, an International Work Group sponsored by the National Diabetes Data Group of the NIH proposed a now generally accepted classification, according to which the insulin-dependent ketosis-prone diabetes, formerly and i...
Diabetes mellitus · A
Seit der Entdeckung der Inselzellen des Pankreas durch LANGERHANS sind 106 Jahre, seit der experimentellen Erzeugung eines Diabetes durch v. MERING und MINKOWSKI 86 Jahre und seit der Gewinnung des Insulins aus tierischen Pankreata durch BANTING und BEST 54 Jahre vergangen. Trotzdem ist ein giiltiges Gesamtkonzept des Diabetes noch nicht gefunden. Atiologie und viele Fragen der Pathogenese bleiben weiterhin im Dunkeln. Unser Wissen iiber Klinik und Therapie, aber auch urn die einzelnen pathoge netischen Schritte bei der Entstehung der Krankheit hat sich dennoch auBeror dentlich vergroBert. Manche Probleme, die in der letzten Auflage nur angedeutet werden konnten, haben sich als weit schwieri...
Cellular Basis of Chemical Messengers in the Digestive System
Cellular Basis of Chemical Messengers in the Digestive System contains the proceedings of an international symposium on the cellular basis of chemical messengers of the digestive system held in Santa Monica, California, on January 16, 17, and 18, 1980. The papers explore the entire spectrum of problems related to the cellular aspects of chemical messengers in the digestive system, with emphasis on which amines and peptides serve these functions and in which neurons and endocrine-paracrine cells each kind of chemical messenger is found. This book is comprised of 28 chapters divided into six sections and begins by considering the nature of gut peptides and their possible functions. The discuss...
Standardization of Epidemiologic Studies of Host Susceptibility
The incidence of insulin-dependent diabetes mellitus (100M) varies dramatically across racial groups and countries, with annual age-adjusted rates of approximately 40/100,000 per year in Finland, but only 0.51100,000 per year in China. Although reasons for these marked geographic differences are unknown, it is likely that genetic variations across populations play a m~or role. To determine the contribution of genetic factors to the global patterns of 100M incidence, international comparative studies are now being undertaken as part of the WHO Multinational Project for Childhood Oiabetes, known as the DIAMOND Project. It is, therefore, necessary to develop and implement epidemiologic standard...
The Pathology of the Endocrine Pancreas in Diabetes
Diabetes mellitus represents one of the most frequent and serious clinical syn dromes in contemporary medicine. Since the end of the nineteenth century, the endocrine pancreas has been implicated in the pathogenesis of this disease. Several pathologists of the twentieth century detected various lesions and mor phologic alterations in the pancreatic islets of diabetic patients, but the patho physiologic basis of their findings remained long obscure. The systematic mi croscopic work of WILLY GEPTS clarified the views and related the variety in histopathology to differences in origin, duration and clinical expression of the disease. Over the past two decades, the concept of a multifactorial ori...
Pathophysiologie und Klinik
Mit Beiträgen zahlreicher Fachwissenschaftler
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