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Rational Drug Design
Drug research and discovery are of critical importance in human health care. Computational approaches for drug lead discovery and optimization have proven successful in many recent research programs. These methods have grown in their effectiveness not only because of improved understanding of the basic science - the biological events and molecular interactions that define a target for therapeutic intervention - but also because of advances in algorithms, representations, and mathematical procedures for studying such processes. This volume surveys some of those advances. A broad landscape of high-profile topics in computer-assisted molecular design (CAMD) directed to drug design are included....
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Dark Work
Tells the story of one state in particular whose role in the slave trade was outsized: Rhode Island Historians have written expansively about the slave economy and its vital role in early American economic life. Like their northern neighbors, Rhode Islanders bought and sold slaves and supplies that sustained plantations throughout the Americas; however, nowhere else was this business so important. During the colonial period trade with West Indian planters provided Rhode Islanders with molasses, the key ingredient for their number one export: rum. More than 60 percent of all the slave ships that left North America left from Rhode Island. During the antebellum period Rhode Islanders were the l...
Towards Higher Categories
This IMA Volume in Mathematics and its Applications TOWARDS HIGHER CATEGORIES contains expository and research papers based on a highly successful IMA Summer Program on n-Categories: Foundations and Applications. We are grateful to all the participants for making this occasion a very productive and stimulating one. We would like to thank John C. Baez (Department of Mathematics, University of California Riverside) and J. Peter May (Department of Ma- ematics, University of Chicago) for their superb role as summer program organizers and editors of this volume. We take this opportunity to thank the National Science Foundation for its support of the IMA. Series Editors Fadil Santosa, Director of ...
When Big Data Was Small
Richard D. Cramer has been doing baseball analytics for just about as long as anyone alive, even before the term “sabermetrics” existed. He started analyzing baseball statistics as a hobby in the mid-1960s, not long after graduating from Harvard and MIT. He was a research scientist for SmithKline and in his spare time used his work computer to test his theories about baseball statistics. One of his earliest discoveries was that clutch hitting—then one of the most sacred pieces of received wisdom in the game—didn’t really exist. In When Big Data Was Small Cramer recounts his life and remarkable contributions to baseball knowledge. In 1971 Cramer learned about the Society for America...
National Union Catalog
Includes entries for maps and atlases.
Natural Locomotion in Fluids and on Surfaces
This volume developed from a Workshop on Natural Locomotion in Fluids and on Surfaces: Swimming, Flying, and Sliding which was held at the Institute for Mathematics and its Applications (IMA) at the University of Minnesota, from June 1-5, 2010. The subject matter ranged widely from observational data to theoretical mechanics, and reflected the broad scope of the workshop. In both the prepared presentations and in the informal discussions, the workshop engaged exchanges across disciplines and invited a lively interaction between modelers and observers. The articles in this volume were invited and fully refereed. They provide a representative if necessarily incomplete account of the field of natural locomotion during a period of rapid growth and expansion. The papers presented at the workshop, and the contributions to the present volume, can be roughly divided into those pertaining to swimming on the scale of marine organisms, swimming of microorganisms at low Reynolds numbers, animal flight, and sliding and other related examples of locomotion.
In Search of Sustainable Water Management
This edited volume adeptly analyzes some of the most salient challenges that face water managers and policy makers: balancing private and public sector roles in water allocation, protecting environmental values and indigenous rights to water, avoiding transboundary water conflicts, and integrating the concept of sustainable development within water policies. . . the chapters in this book are comprehensive and well balanced. . . Kenney and his colleagues have put forth an important contribution to western water policy scholarship. They offer concrete ideas for sustainable water management in the western US informed by international cases, while acknowledging the West s unique political and so...
Organic Chemistry in Action
Contrary to all other books in the field of organic synthesis, this volume combines Corey's methodology, which is based on the concept of synthon and retrosynthetic analysis, with Evans' methodology based on the `Lapworth model' of alternating polarities. Using this approach, the formation of carbon-carbon bonds and the manipulation of functional groups are treated together, whereas the stereochemical aspects are considered separately. Emphasis is laid on the importance of rigid structures, whether in the starting materials, the synthetic intermediates or the transition states, as a means of controlling the stereochemistry of the organic compounds. Enclosed with the book is a copy of a miniprogram (CHAOS) for an IBM PC, or fully compatible computers, which is an interactive program, affording the beginner a fast and easy way of learning, exploring and looking for new synthetic schemes of molecules of moderate complexity. As a textbook on organic synthesis, this volume will be of immense value at university level.
