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Ion Channel Localization
Since the pioneering discoveries of Hodgkin, Huxley, and Katz, it has been clear that specific ion conductance pathways underlie electrical act- ity. Over the ensuing 50 years, there has been ever increasing, and occasi- ally explosive, changes in the scope of efforts to understand ion channel behavior. The introduction of patch clamp technology by Erwin Neher and Bert Sakmann about 20 years ago led to the realization of the great variety of novel ion channel species, and the subsequent revolution in cl- ing has revealed an even greater diversity of the underlying molecular entities. Today, advances in the study of ion channel structure and function c- tinue at a high pace, from angstrom res...
China's Quest for Political Legitimacy
This book examines the new equity-enhancing politics in China in the context of Chinese traditional cognitive patterns of political legitimacy and its implication for Chinese political development in the near future. Based on an analysis of the new governing philosophy, the generation of political elite, and a new set of public policies, the book reaffirms the emergence of a new Chinese polity that infuses one-party rule with limited electoral and deliberative democracies. Unlike many scholars who perceive the contemporary Chinese history as a constant search for democracy, this book takes a very different approach. It asserts that the enduring question in political development in China today is no different from what was sought after throughout Chinese history, namely, the constant search for political legitimacy. Even though the quest for democracy is instrumental to that end, it may not ultimately lead to the embrace of a full-fledged liberal democracy. The new politics is not only a rationalization of the efficiency-based development, but also a major paradigm shift in China's developmental strategy.
Gene Delivery and Therapy for Neurological Disorders
This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors’ laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer’s diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work. Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab. Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.
Index Veterinarius
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China's Elite Politics
ChinaOCOs Elite Politics provides a new theoretical perspective on elite politics in China and uses this theoretical perspective to explain power transfer from Jiang Zemin to Hu Jintao and political dynamics between different factional groups since the Sixteenth Party Congress of November 2002. It explains the transition in structural terms, presents characteristics of ChinaOCOs political elites, and analyzes the balance of power among formal institutions as well as among factional groups. It also examines political interactions between Jiang Zemin and his cronies on the one side and Hu Jintao and his allies on the other over a number of issues: the epidemic of severe acute respiratory syndrome (SARS); ideological institutionalization; the politics over economic overheating; Jiang ZeminOCOs complete retirement; and Hu JintaoOCOs power consolidation in both ideological and personnel terms."
Annual Report
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