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New Frontiers in Gene-Modified T Cell Technology
The development, clinical translation and recent efficacy of novel gene therapies targeting refractory malignancies has led to research that extends this technology to a variety of infectious and rheumatological diseases. Unlike conventional drugs or antibodies, T cells have the potential to target and exert effector function in response to disease in a dynamic manner, acting as a “living drug”. The most efficacious form of gene-modified T cells to date is the chimeric antigen receptor (CAR)-modified T cell, which redirects the specificity of T cells to an antigen expressed by tumor cells. Clinical experience with autologous CAR-T cells, primarily in hematologic malignancies, has underscored the feasibility and safety of the approach, while also demonstrating dramatic and sustained antitumor effects through mechanisms orthogonal to those of traditional anticancer therapies. However, several challenging obstacles must be surmounted in order to improve the broader efficacy of this approach.
Facts and Evidence
This book presents an in-depth discussion on two concepts from the field of philosophy and law, in order to improve our understanding of the relation between “fact” and “evidence” in judicial process. Since fact-finding is a difficult task for judges, proof by evidence has been devised to help them access the truth. However, in the process of judicial fact-finding, there is always a gap between fact and truth. This book covers a wide range of topics, from reflections on the concept of “fact,” “evidence” and “fact-finding” in the field of philosophy and law to individual case studies. As such it is a useful reference resource on the continuing research on the judicial proof process for students and scholars.
Stats and Curiosities
Fascinating stats... useful tips... entertaining topics. Did you know that to make a task seem easier, all you have to do is lean back a little? Or that retail salespeople who mimic the way their customers speak and behave end up selling more? If you like stats like this, are intrigued by ideas, and find connecting the dots to be a critical part of your skill set—this book is for you. Culled from Harvard Business Review’s popular newsletter, The Daily Stat, this book offers a compelling look at insights that both amuse and inform. Covering such managerial topics as teams, marketing, workplace psychology, and leadership, you’ll find a wide range of business statistics and general curiosities and oddities about professional life that will add an element of trivia and humor to your learning (and will make you appear smarter than your colleagues). Highly quotable and surprisingly useful, Stats and Curiosities: From Harvard Business Review will keep you on the front lines of business research—and ahead of the pack at work.
Survival Governance
Preface -- The argument in summary -- Choosing among implausible leaders -- Technology choices -- The geo-energy trilemma and its mis-management -- 'Winners' and 'losers' in hotter worlds -- China's limits to growth -- Backing the bio-digital energy paradigm? -- City pathways to the bio-digital energy paradigm -- India, the Janus energy sovereign -- Survival Governance.
A Dialogue Between Law and History
This book builds on the success of the First International Conference on Facts and Evidence: A Dialogue between Law and Philosophy (Shanghai, China, May 2016), which was co-hosted by the Collaborative Innovation Center of Judicial Civilization (CICJC) and East China Normal University. The Second International Conference on Facts and Evidence: A Dialogue between Law and History was jointly organized by the CICJC, the Institute of Evidence Law and Forensic Science (ELFS) at China University of Political Science and Law (CUPL), and Peking University School of Transnational Law (STL) in Shenzhen, China, on November 16–17, 2019. Historians, legal scholars and legal practitioners share the same ...
MECHANISM MINING OF INTERNATIONAL COMPARISON
The comparison between international purchasing power and real GDP is very important to the judgment of national power and is the main content of national economic statistics. Although the ICP has experienced more than 50 years, its methodological research should continue. This book gives the research pattern, namely "ICP logic diagram", and puts forward more than 50 methodological issues to be considered. The "pure price ratio assumption" and "equal price ratio assumption" and their impact on the ICP data results are analyzed. It also reviews the important literatures on the recent ICP, especially pointing out that the ICP data results have the measurement risk of "anti-basic facts". This book traces back to "Ryten Report" and explores the principles of spatial economic comparison and the corresponding basic concepts of economics.
Electrical Measuring Instruments and Measurements
This book, written for the benefit of engineering students and practicing engineers alike, is the culmination of the author's four decades of experience related to the subject of electrical measurements, comprising nearly 30 years of experimental research and more than 15 years of teaching at several engineering institutions. The unique feature of this book, apart from covering the syllabi of various universities, is the style of presentation of all important aspects and features of electrical measurements, with neatly and clearly drawn figures, diagrams and colour and b/w photos that illustrate details of instruments among other things, making the text easy to follow and comprehend. Enhanci...
Rock Fragmentation by Blasting
Rock Fragmentation by Blasting contains the papers presented at the 10th International Symposium on Rock Fragmentation by Blasting (New Delhi, India, 26-29 November 2012), and represents the most advanced forum on blasting science and technology. The contributions cover all major recent advancements in blasting and fragmentation, from realistic tre
