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The Hippo Signaling Pathway and Cancer
The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorigenesis, and many leading scientists are showing increased interest in this growing field and it's relation to cancer. The chapters in this volume cover virtually all aspects of tumor biology, because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Ras, Wnt, TGFbeta and p53. Moreover, Hippo signaling is not solely involved in regulating “classic” tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. The primary audience are researchers interested in basic science in the areas of tumor suppression, cell cycle and size regulation, development and differentiation.
AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Book of Abstracts
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The P53 Protein
Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signal...
The Modest Genius
Rabbi Yehoshua Aisek Shapira lived in the 19th century and was the great-grandson of Rabbi Luria, the famed Kabbalist of Safed. Rabbi Aisel Slonimer, as he was known, spent most of his rabbinic life in Slonim, in the Grodno district of Byelorussia, He was called Harif (Sharp) because of his prodigious memory and his sharp tongue. His witticisms and clever retorts are legendary. Rabbi Aisel wrote many of his major works in Slonim, including Emek Yehoshua and Nahlat Yehoshua which encompass his responsa (questions and answers to problems of his day); Noam Yerushalmi, his commentary and glosses on the Jerusalem Talmud; and Sefat HaNahal and Ibbei HaNahal which contain many of his sermons.
Israel's Military Operations in Gaza
Civilians in Gaza and Israel are caught up in complex, violent situations that have overstepped conventional battle lines. Both sides of the conflict have found ways to legitimate the use of violence, and continually swap accusations of violations of domestic and international humanitarian laws. Israel’s Military Operations in Gaza provides an ideological critique of the legal, military, and social media texts that have been used to legitimate historical incursions into the Gaza, with special focus on Operation Protective Edge. It argues that both the Palestinians and the Israelis have deployed various forms of ‘telegenic’ warfare. They have each used argumentative rhetorics based on c...
Re-envisioning Jewish Identities
This innovative study combines readings of contemporary literature, art, and performance to explore the diverse and complex directions of contemporary Jewish culture in Israel and the diaspora.
Contemporary Israel
For a country smaller than Vermont, with roughly the same population as Honduras, modern Israel receives a remarkable amount of attention. For supporters, it is a unique bastion of democracy in the Middle East, while detractors view it as a racist outpost of Western colonialism. The romanticization of Israel became particularly prominent in 1967, when its military prowess shocked a Jewish world still reeling from the sense of powerlessness dramatized by the Holocaust. That imagery has grown ever more visible, with Israel’s supporters idealizing its technological achievements and its opponents attributing almost every problem in the region, if not beyond, to its imperialistic aspirations. T...
Newsview
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Evolution by Gene Duplication
It is said that "necessity is the mother of invention". To be sure, wheels and pulleys were invented out of necessity by the tenacious minds of upright citi zens. Looking at the history of mankind, however, one has to add that "Ieisure is the mother of cultural improvement". Man's creative genius flourished only when his mind, freed from the worry of daily toils, was permitted to entertain apparently useless thoughts. In the same manner, one might say with regard to evolution that "natural selection mere(y tnodifted, while redundanry created". Natural selection has been extremely effective in policing alleHe mutations which arise in already existing gene loci. Because of natural selection, o...
