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Myelin: Biology and Chemistry provides in-depth reviews and discussions regarding recent findings in the biology and chemistry of myelin. Topics are interdisciplinary and carry readers from the cellular level to that of the gene. Research in demyelinating diseases (naturally occurring and experimentally produced) is described and emphasizes autoimmune and virally induced mechanisms. Advances in molecular biology, such as those that provide details of the structures of the major myelin proteins, demonstrate the control of their synthesis, and explore the mutations within their genes that disrupt the process of myelination, are discussed in depth. Myelin: Biology and Chemistry will be an important addition to the libraries of molecular biologists, biochemists, cell biologists, physical chemists, immunologists, virologists, and pathologists involved in the study of myelin.
Frank Schmitt has for two thirds of a century been searching for -- and in many cases finding -- explanations of major biomedical importance. His is a very human story -- of a youth in high school doing experiments in a make-shift chemical laboratory in the attic of the family home; of a young university student who organized a students' science society and whose undergraduate research on cell structure was published in major professional journals; of a medical school student who wrote a thesis that attracted the attention of cardiologists for many years; of a devoted husband who, with his young wife, spent two postdoctoral years in Berkeley, London and Berlin and later made two trips around...
This book contains papers which discuss many different stimulus--response systems ranging from those in bacteria and paramecia to those in insects and mammals. Emphasis is placed on the identification and characterization of receptor molecules, physical properties of channel molecules, physical and chemical changes in receptors, channels and other structures after stimuli, and the molecular events in the sequential response, excitation, adaptation and learning phases. Use is made throughout of both traditional and new techniques in electrophysiology, biochemistry, genetics and ultrastructural analysis. By covering a wide range of stimulus--response systems the book invites comparison between systems and generates discussion about common principles underlying information reception, transduction and response.
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