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Metabolic and Senescence Characteristics Associated with the Immune Microenvironment in Tumor Cells
A common feature of cancer metabolism is the ability to obtain essential nutrients from a nutrient-poor environment and use them to maintain viability as well as generate new biomass. Alterations in intracellular and extracellular metabolites can be accompanied by tumor-associated metabolic reprogramming with profound effects on gene expression, cell differentiation, and tumor microenvironment. In these cases, the metabolic microenvironment of the tumor itself can present an immunosuppressive environment that needs to be overcome. Specifically, it will help maximize the efficacy of cancer therapies by identifying targets that suppress or alter cancer metabolism to improve the tumor microenvironment nutrient availability or that modulate immune metabolism to bolster inflammation.
Substance and Energy Metabolism Associated with Neuroendocrine Regulation in Tumor Cells
An increasing number of studies suggest that the abnormality of substance and energy metabolism of tumor cells is among the unsolved complex pathological mechanism problems in malignant tumor. The abnormal metabolism of substance and energy in tumor cells is not only the cause of occurrence and development of malignant tumors, but also the concrete embodiment of their pathological changes. Substance and energy metabolism of tumor cells largely depends on neuroendocrine regulation, so it is of great scientific and clinical significance to analyze its regulatory mechanism. The imbalance of material and energy metabolism of tumor cells is one of the major causes for the occurrence and development of tumors, often regulated by neuroendocrine system. Therefore, neuroendocrine regulation plays an important role in tumorigenesis and development. For example, endocrine diseases such as diabetes and obesity are directly related to the occurrence and development of tumors.
Contemporary World Writers
Concise discussions of the lives and principal works of important living writers of fiction, drama, and poetry who write in languages other than English. Written by subject experts.
Proceedings of the 26th International Symposium on Advancement of Construction Management and Real Estate
This book of CRIOCM 2021 (26th International Conference on Advancement of Construction Management and Real Estate) presents the latest developments in real estate and construction management around the globe. The conference was organized by the Chinese Research Institute of Construction Management (CRIOCM) working in close collaboration with Tsinghua University. Written by international academics and professionals, the book discusses the latest achievements, research findings and advances in frontier disciplines in the field of construction management and real estate. Covering a wide range of topics, including building information modeling, big data, geographic information systems, housing policies, management of infrastructure projects, intelligent construction and smart city, real estate finance and economics and urban planning and sustainability, the discussions provide valuable insights into the implementation of advanced construction project management and real estate market in China and abroad. The book offers an outstanding resource for academics and professionals.
