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Ovarian Aging: Pathophysiology and Recent Development of Maintaining Ovarian Reserve, volume III
Age-related fertility decline is a striking phenomenon for women and there is an increasing tendency for later marriage and the postponement of childbearing in industrial countries. Many epidemiological observations also point out that almost one-tenth of reproductive-aged women require infertility treatment in these countries. Although the uterus is somewhat affected by ageing, the ageing ovary is considered a major but inevitable phenomenon. Consequently, preserving future fecundity is generally understood as preserving ovarian function; this is becoming a major concern for physicians specialized in reproductive medicine. Several chemicals have proved to improve or maintain the ovarian follicular pool, though the efficacy is still limited.
Highly Contiguous Plant Genome Assembly and Transcriptional Regulation
Highly contiguous reference genome sequences are a prerequisite for genomics research and for the optimal utilization of plant species. However, whole-genome duplication events and subsequent chromosomal rearrangements and losses shape the complex features and extensive diversity of plant genomes, and hinder their highly contiguous assembly. With the advent of single-molecule, long-read sequencing technologies, such as PacBio High-Fidelity (HiFi) and Oxford Nanopore Technologies (ONT), as well as Bionano genomics and high-throughput chromatin conformation capture (Hi-C), many highly complex chromosome-level genomes have been revealed, even with phased haplotypes. These advanced sequencing te...
Integrative Multi-Omics for Diagnosis, Treatments, and Drug Discovery of Aging-Related Neuronal Diseases
As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedent...
Ovarian Aging and Reproduction
The ovary plays a very significant role in aging. The regenerative capacity of stem cells is the key factor to promote healthy aging, and the stem cell viability would decline sharply after the reproductive period, especially in women. Except for stem cell aging and neuroendocrine aging, ovarian aging is also a hotspot in the field of aging research. Recent researches have investigated many factors affecting ovarian function or aging, in terms of gene mutation, epigenetic erosion, endocrine dysfunction and environment-dependent extrinsic factors. This Research Topic aims to explore in detail all the factors related to ovarian aging and female reproduction outcomes. We'll discuss various age-...
Characterization of Minerals, Metals, and Materials 2016
Characterization is an important and fundamental step in material research before and after processing. This bookfocuses on the characterization of minerals, metals, and materials as well as the application of characterization results on the processing of these materials. It is a highly authoritative collection of articles written by experts from around the world. The articles center on materials characterization, extraction, processing, corrosion, welding, solidification, and method development. In addition, articles focus on clays, ceramics, composites, ferrous metals, non-ferrous metals, minerals, electronic, magnetic, environmental, advanced and soft materials. This book will serve the dual purpose of furnishing a broad introduction of the field to novices while simultaneously serving to keep subject matter experts up-to-date.
