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Circadian Medicine
Circadian rhythms, the biological oscillations based around our 24-hour clock, have a profound effect on human physiology and healthy cellular function. Circadian Rhythms: Health and Disease is a wide-ranging foundational text that provides students and researchers with valuable information on the molecular and genetic underpinnings of circadian rhythms and looks at the impacts of disruption in our biological clocks in health and disease. Circadian Rhythms opens with chapters that lay the fundamental groundwork on circadian rhythm biology. Section II looks at the impact of circadian rhythms on major organ systems. Section III then turns its focus to the central nervous system. The book then closes with a look at the role of biological rhythms in aging and neurodegeneration. Written in an accessible and informative style, Circadian Rhythms: Health and Disease,will be an invaluable resource and entry point into this fascinating interdisciplinary field that brings together aspects of neuroscience, cell and molecular biology, and physiology.
Principles of Human Locomotion
This book addresses how the general principles of biology influence the human capacity for locomotion, and, conversely, how understanding the nature of muscular activity might provide insights into the basic nature of living beings. Through a series of essays, the book relates the evolutionary basis of animal locomotion to recognizing the determinants of exercise capacity. While raising more questions than providing answers, the discussions will assume that without knowing the correct questions to ask, the answers will not be forthcoming. At the root of this book lies the central query: what is it that separates the principles governing the function of living beings from those that dictate the inanimate world? The discussions here address this issue from the expectation that clues to the answer can be obtained through understanding adaptations to the stresses imposed by physical exercise. As such, the book provides thought-provoking analyses of the biological basis of locomotion that will stimulate future efforts to understand these phenomena.
Mechanisms of Circadian Systems in Animals and Their Clinical Relevance
Well known experts in the field of Chronobiology from around the world, provide an integrative view of the state of the art of circadian biology. At present, genetic and epigenetic interaction of regulatory pathways among circadian oscillators, metabolic networks, cellular differentiation and neuronal communication are subject of intense scrutiny. The book is organized in three sections: The first includes selected examples of the circadian systems of crustaceans, insects, fish, birds and mammals. The second is a detailed view of the physiological mechanisms underlying the circadian clocks in mammals. Finally, in the third section some examples of the relevance of circadian biology and circa...
Chronobiology and Chronomedicine
Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for the difference between life and death in response to identical stimulus. The partly endogenous nature of circadian rhythms has been well documented and methods for their characterisation have been developed enabling the cellular and molecular mechanisms to be understood. Chronobiology and Chronomedicine aims to provide a review of these mechanisms underlying circadian rhythms and illustrate the role of the brain’s suprachiasmatic nuclei in the ‘pace-making’ process and the effects caused by ‘clock genes’ present in almost all cells. Beyond the mechanisms involv...
Demon Lord, Retry! Volume 2
After defeating the Satanists, the Demon Lord meets White – the oldest of the Holy Women – who also fears the Demon Lord’s powers much more than she should. Oblivious to this, the Demon Lord works hard to develop Luna’s village. He begins by building all sorts of non-fantastical facilities, like a field hospital and a hot springs resort, when...
Demon Lord, Retry! Volume 3
Leaving the village of Rabbi in the care of his advisors, the Demon Lord heads North with the adventurers Yukikaze and Mikan in search of an anti-magic solution. However, he enters the Bastille Dungeon during his search to find an unimaginable sight. At the same time, the village development steadily becomes an international success with the help of the influential Madame. Get ready for the third volume of the mistaken-identity fantasy, where a game developer plays a Demon Lord of his own creation!
Demon Lord, Retry! Volume 6
After defeating the Grand Devil Belphegor, the Demon Lord returns from Hellion Territory to his home-away-from-home, the Village of Rabbi. There he summons yet another advisor, this time to handle the maintenance and management of the village. He had hoped to finally make space for some quality time with the friends he’s made in this world, but his well-deserved R&R is cut short when one of the four major political factions in Holylight sparks civil unrest.
Demon Lord, Retry! Volume 4
After defending the city of Rookie from the monsters of the Bastille Dungeon, the Demon Lord decides to seek more answers about this world. He infiltrates Animania with his newly summoned advisor, the two Star Players in tow. Meanwhile, Luna receives news that her childhood best friend, a demi-human, is being shipped to Hellion territory as a slave. Can Luna save her best friend before the fanatical Tzardom of Light carries out their plan? The Demon Lord and party approach the core of the mystery behind the world of Akira Ono’s creation.
