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Evolutionary Biology of Tumor Initiation and Progression
Cancer is characterized by heterogeneous cells with capacity for self renewal, and selective pressures in the microenvironment which constantly change the cell population. This "descent with modification" is consistent with Darwin's definition of evolution, and accordingly, cancer progression can be captured from an evolutionary angle. However, there is also a clear difference between cancer progression and biological evolution. First, contrary to the evolution of complex organisms, cancer originates from cells of multicellular organisms that escape their constraints and behave like unicellular organisms. Therefore, from the beginning, cancer cells have complex genomes that contain abundant genetic materials which they can use to change their phenotype by dynamic rearrangements and modifications. Secondly, epigenetic effects promote cancer evolution in contrast to the evolution of life. Some tumors develop with minimal genetic alterations, and cell plasticity contributes to both initiation and progression in various tumors. However, an evolutionary theory that encompasses these characteristics of cancer remains to be developed.
Diagnostic Cytogenetics
Following a section on tissue culture, chromosome staining and basic information about karyotyping, this text presents nomenclature and quality standards, as well as protocols of relevance to comprehensive cytogenetic diagnostics.
Gateways to the Soul
A guide on how to live more soulfully and, in so doing, transform yourself and the planet • Explores the connections between healing your personal wounds and healing the planet • Explains how embracing unitive qualities such as love, friendship, joy, courage, forgiveness, and truth, as well as facing your Shadow sides and confronting world evil, enables you to move through important gateways leading to soul • Offers a variety of transpersonal exercises, meditations, and guided visualizations Humanity is in a great crisis of soul today, but there is also much good will around. As a species, we are challenged to start embracing a new story, one that enables us to be less greedy and mater...
The Road Back to Me
Healing and Recovering from Co-dependency, Addiction, Enabling, and Low Self-Esteem This story is told through the jagged peephole of the author's awareness, examining her formative wounds and influences from the perspective of a woman who has now gained experience and wisdom. As she peers over her soul's shoulder, she recalls the chaos of her once-fragile childhood mind. She shudders as she is reminded of the sting of her lonely childhood, her feelings of abandonment, and her painful memories of being bullied. Her childhood self was once so lost that she even contemplated suicide. As the years progress, her mind is riddled with obsession, compulsion, and a crippling sense of low self-esteem. A turning point arrives many years later, after marriage and the birth of three children. This story is about healing the faulty programming of childhood. It is about recovery from relationship addiction, food addiction, anxiety, and constant fear. It is a human story that will resonate with readers from all walks of life, and which offers hope to anyone who has felt imprisoned by the past.
Public Relations
Public relations as described in this volume is, among other things, society’s solution to problems of maladjustment that plague an overcomplex world. All of us, individuals or organizations, depend for survival and growth on adjustment to our publics. Publicist Edward L. Bernays offers here the kind of advice individuals and a variety of organizations sought from him on a professional basis during more than four decades. With such knowledge, every intelligent person can carry on his or her activities more effectively. This book provides know-why as well know-how. Bernays explains the underlying philosophy of public relations and the PR methods and practices to be applied in specific cases...
Hematologic Malignancies: Acute Leukemias
Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.
The Topkapi Scroll
Since precious few architectural drawings and no theoretical treatises on architecture remain from the premodern Islamic world, the Timurid pattern scroll in the collection of the Topkapi Palace Museum Library is an exceedingly rich and valuable source of information. In the course of her in-depth analysis of this scroll dating from the late fifteenth or early sixteenth century, Gülru Necipoğlu throws new light on the conceptualization, recording, and transmission of architectural design in the Islamic world between the tenth and sixteenth centuries. Her text has particularly far-reaching implications for recent discussions on vision, subjectivity, and the semiotics of abstract representat...
Just be Yourself, Dragon!
It's Dragon's first day of school, and she's so nervous, she hides under the bed and then under the table. Can you help her?
Marley and the Family Band
A picture book that celebrates music, love, and family from author Cedella Marley. A poetic story about a young girl who moves to a new country and learns to make friends—inspired by a childhood growing up with the musician Bob Marley as a father. When Marley and her family move from Jamaica to Delaware, she knows life is about to change in big ways. And she's got the perfect plan to help her and her siblings make friends: an outdoor concert for the whole neighborhood! But when weather ruins their plans, she discovers help in the most unlikely places as her new neighbors quickly become the kindest of friends. In this joyful, vibrant picture book inspired by her childhood and iconic father, Cedella Marley assures children that nothing can stop the music as long as they have community.
Aeneid Book VI
In a momentous publication, Seamus Heaney's translation of Book VI of the Aeneid, Virgil's epic poem composed sometime between 29 and 19 BC, follows the hero, Aeneas, on his descent into the underworld. In Stepping Stones, a book of interviews conducted by Dennis O'Driscoll, Heaney acknowledged the importance of the poem to his writing, noting that 'there's one Virgilian journey that has indeed been a constant presence, and that is Aeneas's venture into the underworld. The motifs in Book VI have been in my head for years - the golden bough, Charon's barge, the quest to meet the shade of the father.' In this new translation, Heaney employs the same deft handling of the original combined with the immediacy of language and flawless poetic voice as was on show in his translation of Beowulf, a reimagining which, in the words of Bernard O'Donoghue, brought the ancient poem back to life in 'a miraculous mix of the poem's original spirit and Heaney's voice'.
