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Therapeutic Intranasal Delivery for Stroke and Neurological Disorders
The blood-brain-barrier serves to encapsulate and protect the central nervous system, but it also presents a major barricade to therapeutic drug delivery. Poor penetration is the most common hurdle to translating a promising experimental therapy that uses invasive delivery methods to a clinically useful application. In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases. The proposed book will bring together reports from various labs around the world who have had successes in pre-clinical studies of intranasal therapies for various diseases including adult and perinatal stroke, Alzheimer's, Parkinson's, and others.
Stem Cells and Aging
Dr. Borlongan and Dr. Steinberg serve as consultants to stem cell-based companies, hold patents and patent applications, and have funded grants related to stem cell biologics and applications.
Tinhead City, KL
In this dystopian KL, a faceless corporation manages the city and hope is as toxic as the air. Abandoned by his father, 19-year-old Zachary Ti learns to fend for himself in the new, gritty world of KL, a district overrun by tinheads that are issuing capital punishment for the slightest of offences. When he accidentally kills two of the cyborgs, Zach is forced to join an elite rebel faction whose methods are more than questionable. Soon he is sent back into the fray of KL—but this time he is a wanted man.
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