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Fundamentals and Advances in Medical Biotechnology
This book serves as an introduction to the concepts of medical biotechnology, with great details about fundamentals and early disciplines of study as well as emerging fields and the latest research. The book follows a chronological order from the earliest discoveries and breakthroughs of medical biotechnology to the latest areas of study. The book contains up-to-date citations for each chapter and section, which makes it easy for the reader to understand the concept and also to follow the latest developments in the particular area. It is an ideal book for undergraduate and graduate students who aspire to derive basic knowledge and are also keen on learning about the latest advancements in the field of medical biotechnology.
p53
p53 is a protein that plays an important role in the regulation of cell division and thereby offers protection to the cell against malignant transformation. This is the most well-studied and most appreciated role of p53, due to which the protein is famously known as the “guardian of the genome.” It is the most studied protein in all forms of cancer research, with much of this research investigating p53’s role in tumor suppression. However, research has also shown that p53 plays a role in a wide range of other cellular functions, like serving as a biomarker for environmental pollution. Even as a tumor suppressor and transcription factor, many aspects of p53 function are still obscure, and research in the field is continually attempting to shed light on these functions. This book examines and discusses the myriad roles of p53 and different aspects of its functions. Chapters examine p53 in cancer prevention, DNA repair, gene regulation, and more.
Epigenetics to Optogenetics
Epigenetics, which deals with the study of heritable gene expression that takes place independent of changes in DNA sequence, and optogenetics, which deals with the study of genes expressed under the influence of light, are two emerging areas of study and research that have contributed immensely to our current knowledge of mechanisms and disease processes in humans. These disciplines are interrelated in the broader picture of biology and one can be used to change or modify the other. The complexity of the techniques involved in these disciplines often leads to a lack of proper understanding by researchers from other disciplines and the scientific community at large. As such, this book provides simple and easy-to-follow explanations of some of the most exciting areas of research in these disciplines.
Laboratory Manual for Groundwater, Wells, and Pumps
The over-exploitation of groundwater and marked changes in climate over recent decades has led to unacceptable declines in groundwater resources. Under the likely scarcity of available water resources in the near future, it is critical to quantify and manage the available water resources. With increasing demand for potable water for human consumption, agriculture, and industrial uses, the need to evaluate the groundwater development, management, and productivity of aquifers also increases. Laboratory Manual for Groundwater, Wells, and Pumps serves as a valuable resource and provides a multi-disciplinary overview for academics, administrators, scientists, policymakers, and professionals invol...
Sustainability of Natural Resources
Agriculture is the backbone of the economy in most countries and its output can be impacted by climate change effects. India, as well as other countries which are predominantly agricultural are facing various challenges due to increasing population which can be met by technological innovations for sustainable agriculture. Advanced and innovative technologies in agriculture will not only solve the problems of fulfilling the food requirement of the growing population but also sustain agriculture in the future. Sustainability of Natural Resources Planning and Management addresses the advancement of innovative techniques to address the issues of water scarcity and agricultural yield. It discusses various aspects of natural resource management, agriculture micro irrigation, AI applications for water management and impacts of climate change on water resources. This book also deals water resource exploration, planning, recent geographic information system-based studies, groundwater modelling, and related applications. It highlights the optimal strategies for sustainable water resource management and development. It also examines precision farming using remote sensing and GIS techniques.
Plasticulture Engineering and Technology
The utilization of successful plasticulture engineering technology can ideally optimize crop yields and provide both economic and environmental benefits, such as reducing the need for water and fertilizer. This book discusses the myriad important aspects of crop production that utilize plastic, such as micro-irrigation, water management, plastic mulch films, protected cultivation and low tunnels, crop covers, canal linings, silage bags, and more. It also examines the latest methods for vertical farming and technological aspects, such as smart agriculture using the internet of things (IoT).The current state of the art, as well as potential future uses,ofplastics isdiscussed in addition to the...
P53 Tumor Suppressor
P53, a homo-tetrameric protein found in mammalian cells, derives its name from the fact that it settles at around 53KDa position in SDS-PAGE, due to a ,Äúkink,Äù in its structure. In its functional state, p53 forms a homo-tetramer and binds to the promoters of a wide array of genes. Binding of p53 downregulates the transcription of target genes. Most of the gene targets of p53 are involved in cell cycle progression, and therefore, any malfunctions associated with p53 have catastrophic consequences for the cell. The gene encoding for p53 known as TP53 is the most well-studied gene in the entire genome because of being the most highly mutated gene in all cancer types. It is due to this widely accepted and documented ,Äúcell protective feature,Äù that p53 is generally referred to as ,Äúthe guardian of the genome.,Äù In this chapter, we will discuss the involvement of p53 in relation to carcinogenesis. We will also cover the major functions of p53 under normal conditions, major mutations of the TP53 gene, and their association with different forms of cancer.
Advances in Water Management Under Climate Change
Due to increasing population, decreased cultivable land, and mounting scarcity of water, it is essential to optimize the use of available resources. Climate change is occurring across the world but its effect may be local or region-specific, including localized watershed management. In order to minimize these effects, governments and environmental agencies encourage the adoption of "climate-smart" agricultural technologies, which involve implementing plans, programs, and projects to sustain and enhance watersheds. Natural ecosystems, in their altered states, have always been relied upon to support the continuity of agricultural production and ecosystem services, such as flood and erosion con...
Climate Change Impacts
This book comprises the select proceedings of the International Conference on Water, Environment, Energy and Society. The book is divided into four parts. Part I deals with some aspects of climatic characteristics ranging from changes in temperature and sunshine hours to downscaling to global climate patterns and effects of El Niño-Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) on extreme rainfall. Part II covers rainfall analysis, including changes in regional rainfall series, analysis of non-stationarity, summer monsoon and rainfall scenarios. Impacts of climate change are treated in Part III. Change point analysis, greenhouse gas emissions, rainfall variability, water resource...
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