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"Volume 35 covers the biological cycling of iron in oceans; the transport of iron in microorganisms, fungi, and plants; the roles and properties of siderophores; the regulation of iron transport and uptake in animals, plants, and microorganisms, and more. "
This volume contains the proceedings of the FEBS Sym posium on the Biochemistry of Membrane Transport, which was held at the Swiss Institute of Technology, Zlirich, July 18-23, 1976. Of the speakers invited or iginally, only five could not attend the meeting, and of the lectures given, all but one of the texts are published here. Thus, this volume gives a faithful ac count of the way the meeting was originally conceived and actually took place. This Symposium on Biochemistry of Membrane Transport was the first Symposium sponsored by the FEBS outside the yearly FEBS-Meetings, after the Special Meeting on Industrial Biochemistry, which took place in Dublin in 1973, and it reflects the interest...
About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g.,...
An up-to date review of basic research on biomembranes. In thisvolume, foremost experts in the field consider the most importantstructural and functional aspects of biomembranes: - MembraneLipids and Aging - Membrane-bound Enzymes - Ion Channels in Biological Membranes - Anion Exchangers of Mammalian Cell Membranes - Diversity of Transport Mechanisms in Bacteria. The volume is an excellent supplement to 'Biomembranes - PhysicalAspects', also edited by Meir Shinitzky. Together these booksprovide a comprehensive ground for understanding complexphysiological processes. Meir Shinitzky, Ph.D., is a Professor of Biophysics in theDepartment of Membrane Research and Biophysics, The WeizmannInstitute of Science, Rehovot, Israel. Since 1971, his research hasfocused on various aspects of membrane structure and dynamics.Currently his main interest is in manipulation of membrane fluidityfor clinical diagnoses and treatments. He has published extensivelyand is acknowledged worldwide as one of the leading experts in theincreasingly significant field of biomembrane research.
This book discusses in detail the different hypothesis and experimental evidence regarding the neurobiological mechanisms involved in neurodegenerative pathology, with an emphasis in Alzheimer's and Parkinson's disease. Since there are many hypotheses for neurodegenerative diseases, there is a real need for a comprehensive view, allowing for integration of the different views for the pathogenic mechanisms of the disease.
Successful drug use in biology and medicine is often prejudiced by the failure of drugs that are otherwise active in vitro to act as efficiently in vivo. This is because in the living animal drugs must, as a rule, bypass or traverse organs, membranes, cells and molecules that stand between the site of administration and the site of action. In practice, however, drugs can be toxic to normal tissues, have limited or no access to the target and be prematurely excreted or inactivated. There is now growing optimism that such problems may be resolved by the use of carrier systems that will not only protect the non-target environment from the drugs they carry but also deliver them to where they are needed or facilitate their release there. Carrier systems presently under investigation include antibodies, glycoproteins, cells, reconstituted viruses and liposomes. Recent advances in the chemistry of cell receptor and receptor-recognising molecules, llnmunology, and natural and artificial membranes have revealed a multitude of ways in which such carrier systems can be modified or improved upon.
For this updated edition, the treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infections has been expanded. This edition also includes new chapters on the fluoroquinolones and drugs used to treat AIDS.
The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protei...
Transport and Diffusion across Cell Membranes is a comprehensive treatment of the transport and diffusion of molecules and ions across cell membranes. This book shows that the same kinetic equations (with appropriate modification) can describe all the specialized membrane transport systems: the pores, the carriers, and the two classes of pumps. The kinetic formalism is developed step by step and the features that make a system effective in carrying out its biological role are highlighted. This book is organized into six chapters and begins with an introduction to the structure and dynamics of cell membranes, followed by a discussion on how the membrane acts as a barrier to the transmembrane ...
Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and ...