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Laron Syndrome - From Man to Mouse
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.
Lessons from Laron Syndrome (LS) 1966-1992
Laron Syndrome (LS) is a disease characterized by resistance to growth hormone (GH) and caused by molecular defects of the GH receptor, leading to a deficiency of insulin-like growth factor-1 (IGF-1) and a significant impairment of growth. The syndrome is a unique human model of a peptide hormone receptor defect and GH-IGF-1 interaction. It offers the opportunity to study the consequences of long-term IGF-1 deficiency and the role of IGF-1 in growth and metabolism. With the recent biosynthesis of IGF-1 and the initiation of IGF-1 therapy, a whole new world of basic biological interactions is opening up. This volume brings together leading researchers in genetics, endocrinology, pediatrics, biochemistry, physiology and pharmacology to summarize what is now known about LS, and to discuss the lessons learned from studying and treating this disease since its initial description in 1966. Special features include the demography of LS, and the first data on the long-term IGF-1 treatment of a large group of patients.
Psychological Aspects of Diabetes in Children and Adolescents
Abstract: The proceedings of a 1981 conference on childhood and adolescent diabetes and its psychological effects, covers 41 technical papers for medical professionals and psychologists arranged under 4 general themes: 1) emotional factors in the diabetic child; 2) the family environment and diabetic children; 3) psychological factors affecting diabetic control; 4) and psycholigical considerations in treating child diabetics (including the patient-doctor relationship, the multidisciplinary team for diabetes control and therapy, and group counselling strategies). Discussion sessions follow the technical papers under each of the 4 general themes. The papers describe practical experience and research results gathered internationally in an effort to understand the psychological implications of diabetes in children, adolescents, and young adults, and to apply this understanding to improving the treatment of such patients. (wz).
Recent Progress in Medico-social Problems in Juvenile Diabetics
Abstract: The proceedings of a 1981 conference on childhood and adolescent diabetes and its psychological effects, covers 41 technical papers for medical professionals and psychologists arranged under 4 general themes: 1) emotional factors in the diabetic child; 2) the family environment and diabetic children; 3) psychological factors affecting diabetic control; 4) and psycholigical considerations in treating child diabetics (including the patient-doctor relationship, the multidisciplinary team for diabetes control and therapy, and group counselling strategies). Discussion sessions follow the technical papers under each of the 4 general themes. The papers describe practical experience and research results gathered internationally in an effort to understand the psychological implications of diabetes in children, adolescents, and young adults, and to apply this understanding to improving the treatment of such patients. (wz).
