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Transatom Bulletin
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The Oral Microbiome in an Ecological Perspective
The oral cavity harbors an immense diversity of microorganisms, including bacteria, fungi, archaea, protozoa and viruses. At health, oral microbial community is thought to be in a state of homeostasis, even after numerous perturbations (e.g., toothbrushing, food intake) a day. The breach in this homeostasis can occur for instance if the perturbations become too excessive (e.g., frequent carbohydrate intake leading to acidification of the community) or the host is compromised (e.g., inadequate immune response resulting in persistent inflammation of periodontal tissue). Aggressive antimicrobial therapy (e.g., antibiotics in case of periodontal disease or preventive antibiotic therapy before an...
Arabidopsis 2010 and beyond – big science with a small weed
Over the past two decades revolutionary progress in plant biology became possible by focusing resources on a single plant reference system, Arabidopsis thaliana. After the completion of the Arabidopsis genome sequence in the year 2000, a coordinated multinational effort was launched to “determine the function of every gene in Arabidopsis” by the year 2010. While this ambitious goal has not yet been fully achieved, the Arabidopsis genome is now one of the best annotated and serves as the gold standard for plant and other genomes. A large and international community has established genetic toolkits and genomic resources, such as sequence-indexed mutant collections and comprehensive and eas...
House Documents
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