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Protein Misfolding Disorders
Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. These groups of diseases are now classified as Protein Misfolding Disorders. This book gives a comprehensive overview of the possible mechanisms involved in Protein Misfolding Disorders and possible therapeutic strategies to treat these diseases. The Ebook provides the most recent evidence addressing the role of cellular stress responses to neurological diseases, along with therapeutic strategies to alleviate ER stress in a disease context. -- Publisher.
Chembiomolecular Science
At the forefront of life sciences today is the emerging discipline of chembiomolecular science. This new term describes the integration of the frontier fields of chemical biology, chemistry, and pharmacology. Chembiomolecular science aims to elucidate new biological mechanisms as potential drug targets and enhance the creation of new drug therapies. This book comprises the proceedings of the Uehara Memorial Foundation Symposium 2011, which focused on the most recent advances in chembiomolecular science made by leading experts in the field. The book is divided into three main topics. The first is the chemical approach to understanding complex biological systems on a molecular level using chem...
Cosmo Innes and the Defence of Scotland's Past c. 1825-1875
Today, Scotland's history is frequently associated with the clarion call of political nationalism. However, in the nineteenth century the influence of history on Scottish national identity was far more ambiguous. How, then, did ideas about the past shape Scottish identity in a period when union with England was all but unquestioned? The activities of the antiquary Cosmo Innes (1798-1874) help us to address this question. Innes was a prolific editor of medieval and early modern documents relating to Scotland's parliament, legal system, burghs, universities, aristocratic families and pre-Reformation church. Yet unlike scholars today, he saw that editorial role in interventionist terms. His sou...
Oxidative Stress
This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.
Training the Samurai Mind
A fascinating, eclectic collection of writings—spanning four hundred years—on samurai ethos, training, and education, from premier translator Thomas Cleary Through the ages, the samurai have been associated with honor, fearlessness, calm, decisive action, strategic thinking, and martial prowess. Their ethos is known as bushido, the Way of the Warrior-Knight. Here, premier translator Thomas Cleary presents a rich collection of writings on bushido by warriors, scholars, political advisors, and educators from the fifteenth century through the nineteenth century that provide a comprehensive, historically rich view of samurai life and philosophy. Training the Samurai Mind gives an insider’s...
The Future and the Past
This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1978.
Scottish Nationalism and the Idea of Europe
Scottish Nationalism and the Idea of Europe offers fresh insights into the 'pro-European' dimension of Scottish nationalism and its implications for the UK.
Those Not-So-Sweet Boys 6
DETERMINED After his confession at the school festival, Rei and Midori are finally a couple! Things are going well until one day, Midori is scooped up by Rei’s grandmother and forced to attend the Ichijo matriarch’s birthday party. Overwhelmed by the difference between her world and Rei’s, and facing intense pressure, Midori retreats... only to find that Rei is now more distant than ever.
