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Protein Targeting with Small Molecules
Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full rang...
Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules
This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.
Integrated Methods in Protein Biochemistry: Part A
Integrated Methods in Protein Biochemistry: Part A, Volume 677, the latest release in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as DNA and protein engineering to create protein bioswitches with new functions, Interaction and cross-talk of prelamin A with integral membrane zinc metalloproteases, An experimental protocol to study lipid transfer proteins, Synthesis of small heat shock proteins, Druggable p-p interacting sites for Co-chaperone DNAJA1 and its partner proteins, An experimental protocol for glycoconjugate analysis, Methods for proximity-based biotinylation combined with Mass Spectrometr...
Ring And Field Theory
This book is intended as a textbook for a one-term senior undergraduate (or graduate) course in Ring and Field Theory, or Galois theory. The book is ready for an instructor to pick up to teach without making any preparations.The book is written in a way that is easy to understand, simple and concise with simple historic remarks to show the beauty of algebraic results and algebraic methods. The book contains 240 carefully selected exercise questions of varying difficulty which will allow students to practice their own computational and proof-writing skills. Sample solutions to some exercise questions are provided, from which students can learn to approach and write their own solutions and proofs. Besides standard ones, some of the exercises are new and very interesting. The book contains several simple-to-use irreducibility criteria for rational polynomials which are not in any such textbook.This book can also serve as a reference for professional mathematicians. In particular, it will be a nice book for PhD students to prepare their qualification exams.
Concepts and Case Studies in Chemical Biology
Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years. Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists. With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.
Microbial Diversity In Asia: Technology And Prospects
Diversity of microbial forms in nature allows the discovery of new microorganisms that produce different types of bioactive compounds including some which may have specific physiological effects in animals. Asian countries possess numerous pristine and exotic locations for the isolation of new species of microorganisms. Research activities in such sciences have only recently been embarked upon by microbiologists from Asian countries as collaborative ventures. The present volume describes the occurrence of diverse and new microorganisms isolated from different sites in countries in Asia. This book includes papers written by eminent microbiologists on the following topics: microorganisms and metabolites which promote animal and plant growth; microbial versatility and its impact on environmental control; utilization of microbial functions and microbial diversity: isolation, systematics and molecular phylogeny of microorganisms. This volume also contains a section on the importance of culture collection network. The subject material of the chapters has been organized in the context of microbiology in the Asian scene.
Glycoscience: Basic Science to Applications
This book presents the state of the art in glycoscience and proposes a road map for the coming decade, focusing on the potential of glycoscience research to shed light on important basic science issues and give rise to exciting new applications, especially in the field of diagnosis and therapeutics. Individual sections offer in-depth coverage of various topics relating to glycans and biopharmaceuticals, glycans in medical science and medicine, glycan technologies, glycans in food and nutrients, and glycan-related materials and their uses. In addition, the book presents an exemplary training course on glycomics and highlights educational and analytical web resources, and also includes glossar...
Protein–Protein Interaction Regulators
New genomic information has revealed the crucial role that protein-protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the field has advanced with increasing growth in the number of successful PPI regulators. Protein-Protein Interaction Regulators surveys the latest advances in the structural understanding of PPIs as well as recent developments in modulator discovery.
