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This book presents a collection of papers prepared by the researches of the Institute for Problems in Mechanical Engineering of the Russian Academy of Sciences (IPME RAS) on the occasion of the 30th anniversary of the establishment of the Institute. The IPME RAS is one of the leading research institutes of the Russian Academy of Sciences and consists of 18 research units (laboratories). The chapters cover the main research directions of the institute, including nano-,micro-, meso- and macro- mechanics and materials, with ,special emphasis on the problems of strength of materials and service life of structures.
This 6th International Workshop in the series starting in 1969 was held at the Naval Postgraduate School in Monterey, California from 25-29 October, 1982 under the continuing directorship of Heinrich Hora. The co-directorship of the late Helmut Schwarz who helped found the series was assumed by George Miley. Fred Schwirzke served as the local organizer. Following a commemoration for Helmut Schwarz, Heinrich Hora connnented that the long title of the workshop is originally due to Nicholas Bloembergen, who prophetically envisaged that "related plasma phenomena" such as is involved in particle beam fusion is also of enormous interest to the laser connnunity. The en thusiastic response of the wo...
The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (UK),H. Robert Horvitz (US)and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death.*Provides the necessary, trusted methods to carry out this research on the latest techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies *Presents key methods on studying tumors and how these cancer cells evade cell death*Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over
The purpose of the Workshop is to have intensive discussions on both theoretical and phenomenological aspects of strong coupling gauge theories (SCGTs), with particular emphasis on the model buildings to be tested in the LHC experiments. Dynamical issues are discussed in lattice simulations and various analytical methods. This proceedings volume is a collection of the presentations made at the Workshop by many leading scientists in the field.
The purpose of the Workshop is to have intensive discussions on both theoretical and phenomenological aspects of strong coupling gauge theories (SCGTs), with particular emphasis on the model buildings to be tested in the LHC experiments. Dynamical issues are discussed in lattice simulations and various analytical methods. This proceedings volume is a collection of the presentations made at the Workshop by many leading scientists in the field.
Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are act...
This volume examines the current state of free radical biology as it impacts on hepatic disorders. It takes a thorough look at the relationship of oxidative stress in acute and chronic disease and takes into account factors like: redox biomarkers; antioxidant defense and protection; cell signaling, mutations; oxidative damage involving lipids, proteins and nucleic acids; membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function and toxicology and hypoxia. Studies on Hepatic Disorders, the latest volume in the Oxidative Stress in Basic Research and Clinical Practice series, provides a comprehensive look at liver topics. It is organized into four sect...
Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxi...