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Mitochondria in Health and in Sickness
Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in indiv...
Advances in Cancer Biomarkers
At present there are a growing number of biomolecules under investigation to understand their potential role as cancer biomarker for diagnostic, prognostic and therapeutic purposes. Intriguingly, the state of art on cancer biomarkers research shows interesting and promising results together to clamorous failures. Also from a clinical point of view, there are contradictory results on routine clinical use of the present cancer biomarkers. Some patients may be simply monitored in their course by a periodic blood sample, but sometimes this monitoring shows dramatic limits. A lot of patients show serious and extensive relapses without significant change in serum concentrations of biomarkers teste...
Mitochondria and Cancer
Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
Cellular Respiration and Carcinogenesis
Cellular Respiration and Carcinogenesis presents leading experts in the field as it informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanism or pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and contributing authors proficiently and unequivocally address the effects of dysfuncti...
Advances in Cancer Stem Cell Biology
In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.
Gothic Italy
The Gothic, proliferating across different literary, socio-cultural, and scientific spaces, permeated and influenced the project of Italian nation-building, casting a dark and pervasive shadow on Italian history. Gothic Italy explores the nuances, contradictions, and implications of the conflict between what the Gothic embodies in post-unification Italy and the values that a supposedly secular, modern country tries to uphold and promote. The book analyses a variety of literary works concerned with crime that tapped into fears relating to contagion, race, and class fluidity; deviant minds and abnormal sexuality; female transgression; male performativity; and the instability of the new body politic. By tracing how writers, scientists, and thinkers engaged with these issues, Gothic Italy unveils the mutual network of exchanges that informed national discourses about crime. Stefano Serafini brings attention to a historical moment that was crucial to the development of modern attitudes towards normality and deviance, which continue to circulate widely and still resonate disturbingly in contemporary society.
Being Brains
Being Brains offers a critical exploration of neurocentrism, the belief that “we are our brains,” which became widespread in the 1990s. Encouraged by advances in neuroimaging, the humanities and social sciences have taken a “neural turn,” in the form of neuro-subspecialties in fields such as anthropology, aesthetics, education, history, law, sociology, and theology. Dubious but successful commercial enterprises such as “neuromarketing” and “neurobics” have emerged to take advantage of the heightened sensitivity to all things neuro. While neither hegemonic nor monolithic, the neurocentric view embodies a powerful ideology that is at the heart of some of today’s most important philosophical, ethical, scientific, and political debates. Being Brains, chosen as 2018 Outstanding Book in the History of the Neurosciences by the International Society for the History of the Neurosciences, examines the internal logic of such ideology, its genealogy, and its main contemporary incarnations.
Storia irriverente di eroi, santi e tiranni di Napoli
Una galleria di personaggi che hanno lasciato una traccia profonda nella storia della città Che Napoli sia «un paradiso abitato da diavoli» è un adagio che dal Medioevo in poi ha goduto di vasta e ampia fortuna. Ai nostri giorni sembra che l 'antico detto stia più che mai ravvivandosi, specialmente per il degrado del vivere quotidiano, accompagnato da una sistematica inosservanza delle regole. A fare da contrappunto, la costante volontà di chi ancora vuole testimoniare la nobile e secolare storia della città e farne conoscere i complessi monumentali e gli incanti paesaggistici famosi nel mondo. Questo manuale si propone di raccontare la storia curiosa e insolita di tiranni ed eroi, di...
La tempesta invisibile - Nuova edizione
Torri cellulari, Wi-fi, 5G: l'elettricità ha plasmato il mondo moderno. Ma come ha influenzato la nostra salute e l'ambiente? Un'originale ricostruzione dal Settecento a oggi proposta in una nuova edizione.
Мир под напряжением. История электричества: опасности для здоровья, о которых мы ничего не знали
Вышки сотовой связи, километры проводов, wi-fi и мобильные телефоны сформировали наш современный мир. Мы просто не можем себе представить жизнь без электронных средств связи: телевидения, радио, планшетов и ноутбуков. А ведь всего 130 лет назад их не было. Автор проводит расследование того, как электромагнитное загрязнение повлияло на наше здоровье и здоровье планеты в целом. Фактически он наложил карту вспышек заболеваний по всему миру на карту электрификации. И знаете что? Они совпали! Шокирующее исследование от мирового ученого изменит ваше представление о безопасных сотовых и микроволновках.В формате PDF A4 сохранен издательский макет.
