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The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation
The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration.
An Intertextual Commentary on Romans, Volume 2
An Intertextual Commentary on Romans is an exhaustive treatment of the hundreds of Old Testament citations, allusions, and echoes embedded in Paul's most famous epistle. As many scholars have acknowledged, to understand Paul's engagement with Israel's Scriptures is to understand Romans. Despite this acknowledgement, there is a dearth of reference works in which the primary focus is how the Old Testament impacts Paul's argument from Romans 1:1 to 16:27. This four-volume commentary aims to provide just such a reference. The interplay between Romans and its vast sea of Old Testament pre-texts produces unstated points of resonance that illuminate Paul's rhetorical argument from the letter's open...
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Recent Landform Evolution
The Carpatho-Balkan Geomorphological Commission and the International Association of Geomorphologists (IAG) Carpatho-Balkan-Dinaric Regional Working Group, promote networking between researchers and the exchange of research experience. Following a brief introduction into the geology, climate, hydrology and land cover of the Carpatho-Balkan-Dinaric region, the book provides detailed information on research applying both traditional and innovative techniques and summarizes contemporary knowledge on recent geomorphic processes. It also presents studies of exogenic geomorphic processes from each country. The chapters on Poland, the Czech Republic, Slovakia, Ukraine, Hungary, Romania, Slovenia, Croatia, Serbia, Bulgaria and Macedonia examine the geomorphic processes in shaping the topography of each country. This volume also examines key geomorphic processes influencing land use and economic activities as well as contributions discussing processes under climate change.
Brain-immune interactions in health and disease
Brain-immune interactions are essential to maintain health and their dysfunction contributes to diverse human diseases. Recent data show that haematopoietic processes and immune organs are under central autonomic control. Deficient regulation of inflammatory events contributes to brain diseases, whereas acute or chronic brain injury is linked with the development of systemic inflammatory conditions or immunosuppression. At present, common disorders with high socio-economic burden such as cancer, cardiovascular-, neuroinflammatory- and neurodegenerative diseases, asthma, allergies, autism, psychiatric conditions and sepsis are believed to be influenced, at least in part, by the dysfunction of...
