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The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. The transition from cytotoxic chemotherapy to targeted cancer drug discovery and development has resulted in an increasing selection of tools available to oncologists. In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecu...
This book constitutes the proceedings of the 12th International Conference on Transport Systems Telematics, TST 2012, held in Katowice-Ustron, Poland, in October 2012. The 48 papers included in this volume were carefully reviewed and selected for inclusion in this book. Transport telematics are the systems using the information and communication technologies in the area of infrastructure and of means of transport and its participants. An intelligent transport covers systems that allow, through the data transmission and analysis, to influence the behaviour of road users and the action of technical elements in means of transport or along the traffic route. Intelligent transport systems - in accordance with the European Directive - are used for the transport management informatisation. The research shows that the use of telematics can significantly increase the efficiency of the transport system, the road safety and the environmental protection. This book provides an overview of solutions being developed in the field of intelligent transportation systems, and includes theoretical and case studies in the countries of conference participants.
This book addresses hot issues in the research and management of difficult-to-treat medical disorders that are commonly encountered, but for which the underlying mechanisms are often unknown. These include the adverse effects of hemodialysis and its biocompatibility in chronic kidney insufficiency, particularly related to malnutrition and inflammation, or the vulnerability of cancer patients to bacterial meningitis, the infection that remains underdiagnosed due to limited expression of symptoms. The book also covers other key topics, such as the psychological care of lung cancer patients; difficulties in the diagnosis of diffuse axonal injury in traumatic brain injury – a disorder with a p...
Krzysztof Kieslowski’s untimely death came at the height of his career, after his Three Colors trilogy of films garnered international acclaim (and an Oscar nomination), and he had been proclaimed Europe’s most important filmmaker by many critics. Born in 1941, he was only fifty-four years old when he died. Kieslowski himself tried to tell the story of his life and career in the 1993 book Kieslowski on Kieslowski. This collection, by contrast, reveals the shifting voice of a filmmaker who was initially optimistic about his social and cultural role, then felt himself buffeted by the turbulent politics and events of the People’s Republic of Poland. As described in the chronology in this ...
Includes section "Book reviews."
Provides a comprehensive guide to the use of gas chromatography–mass spectrometry (GC-MS) on environmentally significant organic compounds This book presents a library of mass spectra of 1,725 biologically and environmentally important organic compounds, in the form of their trimethylsilyl derivatives (TMS), as well as their linear temperature programmed chromatographic retention indices, RI, whose values are in the range of 700-4700 index units. Of the compounds presented, more than 60% of compounds have not previously been characterized by their mass spectra, and more than 70% not previously been characterized by their RI values. Some of these compounds, never before analysed via MS and ...