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Proteomics: Biomedical and Pharmaceutical Applications
Human biology has now entered into a phase of post-genomics and it might not be an exaggeration to say that the major outcome of the human genome sequencing has finally been to open the way to the exploration of the proteome-proteomics. Proteins are the functional output of genes and there are two main expected outcomes from human proteomics. The first is to discover new molecular markers for early diagnosis and profiling of pathologies. The second is to decipher the intracellular signaling pathways leading to the initiation and progression of pathologies, for the identification of new targets and the development of innovative therapeutic strategies. This is clearly a promising challenge that this book explores through a series of ongoing experiences and projects representative of the new era in which biology and medicine have now entered.
Arthrogryposis
The term arthrogryposis describes a range of congenital contractures that lead to childhood deformities. It encompasses a number of syndromes and sporadic deformities that are rare individually but collectively are not uncommon. Yet, the existing medical literature on arthrogryposis is sparse and often confusing. The aim of this book is to provide individuals affected with arthrogryposis, their families, and health care professionals with a helpful guide to better understand the condition and its therapy. With this goal in mind, the editors have taken great care to ensure that the presentation of complex clinical information is at once scientifically accurate, patient oriented, and accessible to readers without a medical background. The book is authored primarily by members of the medical staff of the Arthrogryposis Clinic at Children's Hospital and Medical Center in Seattle, Washington, one of the leading teams in the management of the condition, and will be an invaluable resource for both health care professionals and families of affected individuals.
Vaccines
Completely revised and updated, this respected reference offers comprehensive and current coverage of every aspect of vaccination--from development to use in reducing disease. It also includes access to a companion Web site for more coverage.
Diagnosis and Management of Addiction and Other Mental Disorders (Dual Disorders)
This book includes a compilation of papers published in 2020 and 2021 focused on dual disorders, which are found in significant and growing numbers in both substance addiction and mental health clinics. These contributions assume a broad perspective ranging from exposure to genetic and neurobiological elements to factors such as personality and quality of life. In all cases, these papers aimed to be transferred to and to benefit clinical practice.
The Ethical Frontier of AI and Data Analysis
In the advancing fields of artificial intelligence (AI) and data science, a pressing ethical dilemma arises. As technology continues its relentless march forward, ethical considerations within these domains become increasingly complex and critical. Bias in algorithms, lack of transparency, data privacy breaches, and the broader societal repercussions of AI applications are demanding urgent attention. This ethical quandary poses a formidable challenge for researchers, academics, and industry professionals alike, threatening the very foundation of responsible technological innovation. Navigating this ethical minefield requires a comprehensive understanding of the multifaceted issues at hand. T...
With Children and Youth
With Children and Youth provides a snapshot of emerging theories and perspectives in the field of child and youth care across North America. Well-known scholars and researchers present new and innovative critical perspectives, written in a provocative manner and reflecting outside-the-box thinking. The book examines from scholarly and practical viewpoints the purpose of child and youth care practice, relational practice, post-modern approaches to thinking about theory and practice, and new and innovative thinking about the professionalization and accreditation of the discipline itself. Some chapters merge thinking about child and youth care with esoteric and literary prose; others use humour and satire as a way to represent both foundational and entirely new directions in the field. With Children and Youth provides no set conclusions or findings about the field; instead, it guides the reader to spaces of controversy, contention, and opportunities for innovation and change. Child and youth care practice and theory, it is argued, is based fundamentally on engagement across generations, cultures, and social positions, and this book exemplifies precisely that.
Clinical Diabetes Research
A practical "how to" guide for multiple methods in metabolism, with a critical and objective discussion of strengths, limitations, and appropriate applications of the described methods. Edited by the winner of the Oskar-Minkowski Prize of the EASD in 2006 Clinical trials in populations at risk of or with overt diabetes mellitus are being performed all around the world to test novel drugs and approaches to managing these diseases. During the last decade, new methods and techniques have been introduced – and are being developed further – that facilitate monitoring of metabolism and even diagnosis of certain defects in human metabolism. While some of these methods are restricted to research...
Biotechnology and Ecology of Pollen
In Recognition of the Forgotten Generation D. L. MULCAHyl Pollen was long believed to serve primarily a single function, that of delivering male gametes to the egge A secondary and generally overlooked value of pollen is that it serves to block the transmission of many defective alleles and gene combinations into the next generation. This latter function comes about simply because pollen tubes carrying defective haploid genotypes frequently fail to complete growth through the entire length of the style. However, the beneficial consequences of this pollen selection are diluted by the fact that the same deleterious genotypes are often transmitted through the egg at strictly mendelian frequenci...
