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The Medicinal Chemistry of Glucocorticoid Receptor Modulators
This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the application of prodrugs to GRMs, selective GRMs, targeted delivery of GRMs using polymers and nanoparti...
Hobson's Choice
The Heinemann Plays series offers contemporary drama and classic plays in durable classroom editions. Many have large casts and an equal mix of boy and girl parts. Hobson's Choice is a comedy based around the battle of wills between a hard-headed cobbler and his defiant daughter.
Sales Methods and Policies of a Growers' National Marketing Agency
And general conclusions. pp. 48.
Progress in Medicinal Chemistry
Progress in Medicinal Chemistry, Volume 62 provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors. Provides extended, timely reviews of topics in medicinal chemistry Contains targets and technologies relevant to the discovery of tomorrow’s drugs Presents analyses of successful drug discovery programs
The Hypogeum
Alma Baines is an ordinary woman whose life is irrevocably turned upside down when she loses everything she holds most dear. The forces of darkness want her life to end for reasons she does not truly understand, and only the intervention by a small group of heroes can save her. The forces of darkness are strong and powerful, led by the demon Baphomet,who is willing to go to any lengths to achieve his aim, which is nothing less than the total subjugation of the Earth and every living thing on it. The only ones who can stand against him are the Warrior, the Magician, the Shield, the Joker and the Mother, all of whom are joined by a special connection to the Forest that seems to know more than it is willing to admit.What links the formation of a volcano and an earthquake at opposite ends of the Earth, thousands of years ago with Stonehenge, Woodhenge and Old Sarum. And why is rural Wiltshire the setting for the ultimate battle between good and evil that will determine the fate of the entire planet.
Shekina Island
Colonel Adrian Macalister, a Colonel in the military of the United Collective (a one world governmental society ruled by ten of the most elite men and women in the world) crashes on a remote island hundreds of thousands of miles outside of the UC's border. He and his men are badly wounded, some dead. He discovers that the island is a Utopian society governed and dominated by strong, beautiful, and intelligent women. Men are the sag of the society. Although they are productive in this culture, they are reduced to slaves; cooks, servants, pleasers of women when summoned and to assist in procreation. The island is ruled by a Feminist Queen, Judea Amun and her general Mesara Salento, an emotionl...
