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Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and t...
Japanese encephalitis and West Nile viruses are members of the Japanese encephalitis serological group of the genus Flavivirus and therefore closely related genetically and antigenically. They share a number of properties, including the use of birds as their major wildlife maintenance host and Culicine mosquitoes for transmission, and they are both associated with severe human disease, as well as fatal infections in horses. The emergence of these two viruses, and their well-established propensity to colonise new areas, make it timely to re-examine their ecology, biology, molecular structure, replication and epidemiology, and these therefore provide the focus of this volume.
A significant number of diseases are carried by insects, ticks, mites and rodents, and these diseases are far more common than is often realised. New diseases are regularly discovered and are becoming increasingly widespread, in part due to increased global travel and possibly even climate change. In this exciting new volume Norman Gratz, former Director, Division of Vector Biology and Control, World Health Organisation, reviews the distribution of all currently identified vector and rodent-borne diseases in Europe, the USA and Canada. Each type of infection is presented by group, covering incidence and prevalence, costs and public health burdens. Basic vector biology and control is described in detail and an extensive bibliography is provided to aid readers seeking further information. With its comprehensive coverage and detail, this book is set to become the standard reference for anyone working on vector- and rodent-borne diseases in medical entomology, zoology, epidemiology and public health.
Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.
Tropical Infectious Diseases: Principles, Pathogens and Practice, by Drs. Richard L. Guerrant, David H. Walker, and Peter F. Weller, delivers the expert, encyclopedic guidance you need to overcome the toughest clinical challenges in diagnosing and treating diseases caused by infectious agents from tropical regions. Sweeping updates to this 3rd edition include vaccines, SARS, hepatitis A-E, Crimean-Congo hemorrhagic fever virus, tick-borne encephalitis and Omsk hemorrhagic fever, human papilloma virus, and mucormycosis. New full-color images throughout allow you to more accurately view the clinical manifestations of each disease and better visualize the life cycles of infectious agents. Defin...
An innovative study of colonialism in China, examining Shanghai's International Settlement as the site of key developments in the Republican period.
The Pathogens of Finance is an exploration of how the rising power and profits of Wall Street underpin the contemporary increases in and inadequate responses to vector-borne disease. Over the past fifty years, insects have transmitted infectious diseases to humans with greater frequency and in more unexpected places. To examine this phenomenon, Brent Z. Kaup and Kelly F. Austin take readers to the exurban homes of northern Virginia; the burgeoning agricultural outposts of Mato Grosso, Brazil; and the smallholder coffee farms of the Bududa District of eastern Uganda. Through these case studies, the authors illuminate how the broader financialization of society is intimately intertwined with both the creation of landscapes more conducive to vector-borne disease and the failure to prevent and cure such diseases throughout the world.
This unique volume presents an up-to-date review of one of the world's major health problems — diseases caused by the four dengue viruses. It begins with an insightful story of the origin of dengue disease outbreaks, including the emergence of severe and fatal dengue hemorrhagic fever. The nature, structure and biology of the four dengue viruses are described, and a major portion of the book is focused on the epidemiology of dengue as a mosquito-borne disease. This is complemented by critiques of existing mosquito control programs by three groups of outstanding authorities. The strongest element of the volume is its comprehensive description of the current understanding of dengue disease pathogenesis, followed by an analysis of the pros and cons of five of the most controversial areas in the field: the WHO DEF case definition, secondary dengue infections, virulent viruses, the role of abnormal T cells and autoimmunity./a
Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research. - Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions - Descibes the technologies that have contributed to our current knowledge about the Flaviviruses - Identifies the major problems faced in understanding the virus-host interactins that result in disease - An exhaustive compendium of current and past knowledge on the Flavivirus family