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Brain Stimulation
Deep brain stimulation (DBS) is a neurosurgical intervention whose efficacy, safety, and utility have been shown in the treatment of movement disorders. For the treatment of chronic pain refractory to medical therapies, many prospective case series have been reported, but few have published findings from patients treated during the past decade using current standards of neuroimaging and stimulator technology. We summarize the history, science, selection, assessment, surgery, and personal clinical experience of DBS of the ventral posterior thalamus, periventricular/periaqueductal gray matter, and, latterly, the rostral anterior cingulate cortex (Cg24) in 100 patients treated now at two center...
Landmark Papers in Neurosurgery
Evidence-based medicine is a concept that has come to the fore in the past few years. Clinicians are increasingly encouraged to practise patient management based on available evidence in the scientific literature. For example, new pharmacological therapies are only used when large randomized trials have 'proven' that a particular drug is better than existing ones. This is also the case in surgical specialties, although surgery has traditionally seen a lack of use of this information, with individual surgeon's preferences being most influential in treatment choices. However, more recently, there has been a large expansion of trials and studies aimed at providing surgeons with information to guide their choices using firm evidence. This book provides a detailed summary of the most important trials and studies in neurosurgery, allowing the reader to rapidly extract key results. Each chapter is written by a prominent international neurosurgeon in that particular field, making this book essential reading for all neurosurgeons and trainees in the field.
Landmark Papers in Neurosurgery
This book provides a detailed summary of the most important trials and studies in neurosurgery, allowing the reader to rapidly extract the key results of all major trials.
Surgery of the Autonomic Nervous System
Autonomic surgery is an important and expanding field within contemporary clinical practice. Surgical therapies influencing the autonomic nervous system have historically entailed disabling various components of its network by injurious methods. More sophisticated techniques have now emerged to allow modulation of neural function by electrical implants or by preservative surgery. This has fuelled the expansion in this field as safer therapies with greater scope for patient benefit have become available. As the potential for precise neural manipulation has advanced, so has the number and diversity of diseases which have become amenable to such therapies. This book reviews the basic science un...
Neuromodulation for Intractable Pain
Over 7% of the Western population suffers from intractable pain. Despite pharmacotherapy, many patients (1.5%) suffer from refractory pain. In addition to the pain, patients continue to be highly debilitated and suffer from depression and anxiety, poor quality of life and loss of employment. An ever enlarging global problem concerns the use of opiates which have risen to dangerous levels. Neuromodulation of the nervous system—where the function of the nervous system is altered by a device—has, over time, emerged as an effective alternative to pharmacotherapy in the management of these patients. In this Special Issue, we discussed the indications, safety, efficacy, mechanisms of action and other aspects of neurmodulation therapies for pain relief. These include peripheral nerve stimulation, peripheral field stimulation, spinal cord stimulation, dorsal root ganglion stimulation, motor cortex stimulation and deep brain stimulation. We do not intend this Special Issue to be a comprehensive study of pain but a guide to help clinicians to refer patients appropriately and to decide which procedure would best be offered in certain situations.
The London Gazette
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The Monthly Magazine
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Alexander of Macedon, 356-323 B.C.
This biography portrays Alexander as both a complex personality and a single-minded general, a man capable of such diverse expediencies as patricide or the massacre of civilians. Writing for the general reader, the author provides gritty details on Alexander's darker side while providing a gripping tale of Alexander's career.
